Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2023, 4(5); doi: 10.25236/AJMHS.2023.040505.

Progress in Proteomic Mass Spectrometry Studies on the Effects of Borneol and Menthol as Enhancers on Corneal Injury Repair


Jiaxin Zheng1, Zexiong Li1, Qingping Xia2

Corresponding Author:
Qingping Xia

1Mudanjiang Medical College, Mudanjiang, China

2Department of Science and Education, the People’s Hospital of Gaozhou, Maoming, China


Cornea transparent, avascular tissue, is an important part of the refractive function. Corneal injury is the destruction of the corneal structure caused by blunt eyeball, external force, high pressure gas or fluid hitting the cornea. Common in boxing injury, ball injury, stone injury, head collision, etc. The external force directly acts on the formation of the cornea, mainly manifested as vision loss, pain, photophobia, tears, ciliary congestion and contusion corneal edema. Mild corneal damage can be restored under the strong self-healing ability of the corneal epithelium. If serious corneal damage, the corneal stromal layer will leave a scar on the cornea to affect the vision, but also likely to cause related complications, and even lead to complete blindness. Recent studies have shown that corneal alkali burn is one of the most common eye injuries. Due to the strong corrosion of alkaline substances, it can cause degeneration and dissolution of corneal tissue proteins. The lipophilic properties of alkaline substances make it difficult to limit the damage site and easy to form ulcers. In this paper, we discuss the borneol and menthol on the corneal damage repair mass spectrometry, through the influence of borneol and menthol on corneal damage repair and the preliminary test of ice and menthol can be used, in order to provide a new clinical treatment of corneal damage to the new research direction.


borneol, menthol, permeagent, cornea

Cite This Paper

Jiaxin Zheng, Zexiong Li, Qingping Xia. Progress in Proteomic Mass Spectrometry Studies on the Effects of Borneol and Menthol as Enhancers on Corneal Injury Repair. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 5: 26-30. https://doi.org/10.25236/AJMHS.2023.040505.


[1] Zhao Yangyang, Guo Yuhong, Huang Shanmei, et al. Research progress on the role of borneol in inducing menstruation and its molecular mechanism [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2021, 37 (1): 150-155.

[2] Su Kunlian, Fan Yongjie, Liu Yuan, et al. Research progress on the pharmacological effects and mechanisms of borneol on the cardiovascular and cerebrovascular systems [J]. Liaoning Journal of Traditional Chinese Medicine, 2018, 45 (9): 2001-2003. 

[3] Cha Ying, Guan Lingliang, Bai Lin, et al. Research progress on natural borneol [J]. Tropical Agricultural Science, 201 9, 39 (3): 97-104. 

[4] Wang Can. A Study on the Promoting Osmotic Effect of Borneol on Traditional Chinese Ophthalmology External Medications [J]. Chinese Journal of Basic Medicine of Traditional Chinese Medicine, 2002, 8 (6): 46-54.

[5] Yang Hongbin, Li Zhijian, Yu Nannan, et al. The effect of borneol on the permeability of the blood eye barrier [J]. International Journal of Ophthalmology, 2008,8 (8): 1576-1578.

[6] Sun Xiaoping, Ou Lijuan, Mi Suiqing, et al. Experimental study on the anti-inflammatory and analgesic effects of borneol [J]. New Traditional Chinese Medicine and Clinical Pharmacology, 2007, 18 (5): 353-355.

[7] Liu Leigang. Pharmacological research and clinical application of borneol [J]. Chinese Pharmacoeconomics, 2014, 9 (2): 26-27.

[8] Borges GÁ, Elias ST, da SSM, et al. In vitro evaluation of wound healing and antimicrobial potential of ozone therapy [J]. J Craniomaxillofac Surg. 2017. 45(3):364-370.

[9] Sheyla González, Heui Uhm, Sophie X Deng. Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro[J]. Scientific reports, 2019, 17;9( 1):10373.

[10] SamahKandeel, Mohamed Balaha. Olopatadine enhances recovery of alkali-induced corneal injury in rats[J]. Life Science, 2018,207:499-507.

[11] Nidhi Gupta, Aastha Singh, Umang Mathur. Scleral Ischemia in Acute Ocular Chemical Injury: Long-Term Impact on Rehabilitation With Limbal Stem Cell Therapy [J]. Cornea, 2019,38(2):198-202.

[12] Zuhair Sharif, Walid Sharif. Corneal neovascularization: updates on pathophysiology, investigations & management[J]. Romanian Journal of Ophthalmology, 2019;63( 1):15-22.

[13] Yang Shilin. Research progress on corneal alkali burn [J] Chinese Journal of Traditional Chinese Medicine Ophthalmology, 2006,16 (1): 60-62 .

[14] Jieying Guan, Lijia Zhou, Li Wang, et al. Germinal peptide eye drops promote corneal wound healing and decrease inflammation after alkali injury[J]. Experimental Eye Research, 2020, 199.

[15] Yu Jianfeng, et al."Upadacitinib inhibits corneal inflammation and neovascularization by suppressing M1 macrophage infiltration in the corneal alkali burn model." International Immunopharmacology 116 .(2023). doi:10.1016/J.INTIMP.2023.109680.

[16] Ljubimov AV, Saghizadeh M. Progress in corneal wound healing. Prog Retin Eye Res. 2015 Nov; 49: 17-45. doi: 10. 1016/j.preteyeres. 2015.07.002.

[17] Li Zhilin, Zheng Zujie, Li Xiaodong, Zeng Jieping. Study on the effect of borneol on promoting the permeability of breviscapine through the extracorporeal blood-retinal internal barrier [J]. World Science and Technology Modernization of Traditional Chinese Medicine, 2022-24 (11): 4260-4268.

[18] Zhang Yingrui, Wang Jian, Dong Taiwei, Chen Nian, Hu Qiongdan, Fan Yamei. Research progress on the mechanism of borneol's effect on blood-brain barrier permeability [J]. Traditional Chinese patent medicines and simple preparations, 2020, 42 (12): 3236-3240.

[19] Li Zhilin. Study on the Establishment of Extracorporeal Blood Retinal Barrier and the Role of Borneol in Promoting Breviscapine Translucency Barrier [D]. Chengdu University of Traditional Chinese Medicine, 2020.

[20] Guo Shujuan. Study on the penetration promoting laws and mechanisms of borneol on different traditional Chinese medicine components [D]. Beijing University of Traditional Chinese Medicine, 2019.

[21] Yang Caixia, Zhang Qiuju, Xu Mingshui, Zhang Weiping, Yang Xue, Li Shunan, Wang Yinquan. Research progress on the effect of borneol on blood-brain barrier permeability and its promoting effect on drug permeability [J]. Journal of Gansu University of Traditional Chinese Medicine, 2018,35 (4): 96-99.

[22] Chen Zhongjian, Zhang Yuan, Zheng Yejiao, Yang Haiyan, Gu Liqiang. Research progress of borneol in promoting drugs to penetrate the blood-brain barrier [J]. traditional Chinese patent medicines and simple preparations, 2019, 41 (09): 2170-2173.

[23] Sun Zilin, Xiao Shuang, Peng Mingli. Research progress of curcumin in the treatment of metabolic fatty liver disease [J]. Chinese Journal of Modern Applied Pharmacy, 2023, 40 (07): 1001-1008.

[24] Wu Qingzhi, Gao Qiuhua, Zhu Yushan, Xu Huibi. Study on the promoting effect of borneol on insulin transmucosal absorption [J]. Journal of Huazhong University of Science and Technology, 2001 (S1): 41-43.

[25] Liu Binglei. A study on the effect of borneol on the absorption of ligustrazine into the brain through the nasal cavity and the expression level of mucin in the nasal mucosa [D]. Guangzhou University of Traditional Chinese Medicine, 2015.

[26] Wang Ran, Shi Xinyuan, Yang Shufang, Dai Xingxing, Qiao Yanjiang. A multi-scale study on the transdermal penetration promoting effect of borneol on fluorouracil [J]. Global Journal of Traditional Chinese Medicine, 2017, 10 (5): 517-522.

[27] Kamatou G P, Vermaak I, Viljoen A M, et al. Menthol:a simple monoterpene with remarkable biological properties[J].Phytochemistry, 2013, 96:15. 

[28] Lan Yi, Wang Jingyan, Tao Ye, Ru Qingguo, Wang Yifei, Yu Jingxin, Liu Yan, Wu Qing. Comparative study on the promotion of percutaneous absorption of traditional Chinese medicine components by peppermint oil and menthol [J]. Chinese Journal of Traditional Chinese Medicine, 2016, 41 (08): 1516-1522.

[29] Wang Jingyan, Lan Yi, Lin Hongmei, Zhao Bochen, Liu Yan, Ru Qingguo, Yu Jingxin, Wang Yifei, Wu Qing. Study on the transdermal absorption of effective components of traditional Chinese medicine with different logP values promoted by menthol [J]. Chinese Journal of New Drugs, 2016, 25 (2): 202-209.

[30] Zhang Yi, Yang Kaili, Bi Jiayao, etc. Effects of menthol and styrax volatile oil on transport behavior of ligustrazine nanoparticle across blood brain barrier model [J]. Global Traditional Chinese Medicine, 2022, 15 (2): 188-196.