To investigate the pathological effects of intraoperative rapid freezing and postoperative paraffin section in thyroid cancer, totally 297 patients with thyroid lesions undergoing surgery were selected from Huangshi Aikang Hospital. All patients underwent intraoperatively rapid freezing and postoperative paraffin section. The diagnostic results of benign and malignant thyroid lesions were compared between the two methods. The diagnostic accuracy of frozen section was 92.55% (87/94), with 210 cases of benign and 87 cases of malignant. The diagnosis of paraffin section showed that 203 cases were benign and 94 cases were malignant. Compared with the diagnosis of postoperative paraffin section, the intraoperative rapid freezing section has higher consistency, higher diagnostic accuracy and shorter production time.

Zhou Zhiling. Pathologic analysis of intraoperative rapid freezing and postoperative paraffin section of thyroid cancer. Frontiers in Medical Science Research (2023) Vol. 5, Issue 7: 62-66. https://doi.org/10.25236/FMSR.2023.050709.

[1] WANG G J. Comparative study of rapid freezing during operation and paraffin section diagnosis of thyroid cancer [J]. Chinese Journal of Practical Medicine, 2018, 45 (5) : 79-82.

[2] Wang B C. Diagnosis and misdiagnosis of frozen section of 83 patients with intraoperative thyroid cancer [J]. Journal of Mathematical Medicine and Pharmacology, 2017,30 (12) : 1772-1774. (in Chinese) 

[3] Xiong Jinjin. Comparative analysis of intraoperative freezing diagnosis results and postoperative paraffin section pathological diagnosis results in breast cancer patients [J]. Current Medicine, 2018,24 (11) : 122-124. (in Chinese) 

[4] Yang Cheng. Diagnostic value of intraoperative freezing pathology in intraductal papillary tumor of breast (IDPN) [J]. Modern Medical and Health Research Electronic Journal, 2018, 2 (18) : 64,66.

[5] Fu Na, Sun Chunxia, Sudan Hua. To explore the value of intraoperative rapid frozen section in the diagnosis of ovarian cancer [J]. Chinese and Foreign Women's Health Research, 2018,26 (9) : 61

[6] Su Xu. To explore the clinical value of rapid paraffin section technique for pathological examination [J]. World Latest Medical Information Digest, 2018,18 (98) : 225.

[7] Wang Zhengmin, Wang Yu, Tong LAN, et al. Analysis of influencing factors of false negative results of FNAC in the diagnosis of thyroid cancer [J]. Chinese Journal of Experimental Diagnostics, 2017,21 (5) : 792-794.

[8] Dong Ying, Dong Zhiheng, Wang Dan, et al. Preliminary study on the application of conventional paraffin section technique in experimental teaching of pathology cases [J]. Journal of Jilin University of Chemical Technology, 2017, 34 (2) : 94-96.

[9] Wang Xueli, DANG Shouqin. Pathological diagnosis and clinical value of intraoperative frozen section of ovarian tumor [J]. Chinese Journal of Practical Medicine, 2018,13 (16):41-42. (in Chinese)

[10] Lloyd RV, Erickson LA, Casey MB, Lam KY, Lohse CM, Asa SL, Chan JK, DeLellis RA, Harach HR, Kakudo K, LiVolsi VA, Rosai J, Sebo TJ, Sobrinho-Simoes M, Wenig BM, Lae ME. Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma[J]. Am J Surg Pathol. 2004, 28(10):1336-40.

[11] Grisales J, sanabria A. utility of routine fbzen section of thyroid nodules classified as fouicular neoplasm[J]. Am J clin Pathol, 2020, 153(2): 2lO-220. 

[12] Sanabria A, Zafereo M, Thompson LDR, Hernandez-Prera JC, Kowalski LP, Nixon IJ, Shaha A, Rodrigo JP, Mäkitie A, Poorten VV, Suarez C, Zbären P, Rinaldo A, Ferlito A. Frozen section in thyroid gland follicular neoplasms: It's high time to abandon it[J]. Surg Oncol. 2021 Mar;36:76-81.

[13] Giuliani D, wiuemsen P, Verhelst J, “et al. Fmzen section in thyroid surgery[J]. Acta chir Belg, 2006, 106(2): 199—201. 

[14] Taxy J B , Antic T .Thyroid frozen section: supplementary or unnecessary?[J].American Journal of Surgical Pathology, 2013, 37(2):282-286.