We systematically searched the Cochrane Library, EMbase, PubMed, Web of Science, China Journal Full-text Database (CNKI), Wanfang Digital Journal Full-text Database (Wanfang) and VIP journal Resource integration Service platform (VIP) database for published literature studies on the risk factors for chronic post-surgical pain (CPSP) in total knee arthroplasty (TKA) patients. The search period is up to March 10, 2023. Literature screening and data extraction were conducted independently by two researchers according to inclusion and exclusion criteria. After quality evaluation, meta-analysis was performed using Review Manager 5.3 software. Finally, 17 literatures were included. The results of meta-analysis showed that female [OR=1.32,95% CI(1.18,1.48),P<0.001], preoperative pain [OR= 1.76,95%CI(1.54,2.01),P<0.001], extensive pain[OR=3.11,95%CI(2.07,4.68),P<0.001], preoperative anxiety (OR = 2.80, 95% CI (0.83, 17.30), P < 0.001), preoperative depression (OR = 1.15, 95% CI (1.33, 5.87), P = 0.003] were TKA patients CPSP risk factors. Therefore, Clinical staff should identify and intervene in patients with high risk of CPSP after TKA as early as possible to reduce its incidence.

Xinjian Ai, Yin Yang, Xinyu Zhang. Risk factors of chronic pain after total knee arthroplasty: a meta-analysis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 7-13. https://doi.org/10.25236/FMSR.2023.050802.

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