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Frontiers in Medical Science Research, 2023, 5(8); doi: 10.25236/FMSR.2023.050805.

Literature Analysis of 53 Cases of Sindilizumab-Induced Adverse Drug Reactions


Zheng Chao1, Chen Jie2

Corresponding Author:
Chen Jie

1Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 710046, China

2Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003, China


To examine the pattern of sindilizumab's adverse drug reactions (ADRs) and to offer a literature foundation for the medication's sensible therapeutic administration. The databases of the China Knowledge Network (CNKI), Wanfang, Wipu, PubMed, and Web of Science were searched for literature on Sindilizumab. The information on the timing, systems implicated, clinical symptoms, and reversal of adverse reactions was analyzed and summarized after the literature was compiled and its distribution examined.The 53 cases were spread throughout 51 literature papers, the first case report on Sindilizumab ADRs being published in 2020. The patients' ages ranged from 29 to 87, with a mean of 59.90 years. There were 38 men and 15 women among them. In all, 12 cases (22.2%) of the ensuing ADRs involved the endocrine system, which was then followed by the skin, digestive system, and neurological system. Sindilizumab should be monitored and followed up and documented during the course of drug administration, and ADRs should be detected and dealt with in a timely manner to avoid exacerbation.


Sindilizumab; Adverse effects; Literature analysis; Safety; CRS

Cite This Paper

Zheng Chao, Chen Jie. Literature Analysis of 53 Cases of Sindilizumab-Induced Adverse Drug Reactions. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 36-44. https://doi.org/10.25236/FMSR.2023.050805.


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