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Frontiers in Medical Science Research, 2023, 5(8); doi: 10.25236/FMSR.2023.050810.

Research Progress on the Mechanism of Evodiamine against Hepatocarcinoma


Junwei Li1, Junxuan Chen2

Corresponding Author:
Junxuan Chen

1Traditional Chinese Medicine College, Traditional Chinese Medicine University of Guangzhou, Guangzhou, 510006, China

2School of Public Health and Management, Traditional Chinese Medicine University of Guangzhou, Guangzhou, 510006, China


China is a region with high incidence of liver cancer. The incidence of liver cancer accounts for more than 50% of the global incidence. As early as in the "Shengnong Herbal Classic" recorded: " warms qi in the middle, pain relief, cough against cold and heat, dehumidification, blood bi, wind evil, open Zou Li." Modern pharmacological studies have shown that Evodiamine can significantly inhibit the proliferation of cancer cells, promote the apoptosis of cancer cells, block the cycle of cancer cells, and inhibit the invasion and metastasis of liver cancer cells. At present, studies on the mechanism of Evodiamine's anti-liver cancer action mainly focus on several pathways, and most of them are cell and animal experiments. The effective components and dose-effect relationship of Evodiamine against tumor are not perfect, and relevant studies on drug-fast and body immunity are lacking. In the future, the above points can be further studied to provide a new scientific basis for clinical application.


liver cancer, evodiamine, mechanism of action, review

Cite This Paper

Junwei Li, Junxuan Chen. Research Progress on the Mechanism of Evodiamine against Hepatocarcinoma. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 74-78. https://doi.org/10.25236/FMSR.2023.050810.


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