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Frontiers in Medical Science Research, 2023, 5(8); doi: 10.25236/FMSR.2023.050811.

Advances in the study of the effects of chronic periodontitis on cardiac arrhythmias

Author(s)

Chen Hong1, Wenxian Fan2, Mirigul·Mahsut1, Madina·Abdullam1, Nurjan·Wresdem1, Merhaba·Yasen1, Xinshang Li1,2

Corresponding Author:
Chen Hong
Affiliation(s)

1Department of Endodontics, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, 830054, China

2Institute of Stomatology, Xinjiang Uygur Autonomous Region, Urumqi, 830054, China

Abstract

Periodontitis is a disease that is currently receiving urgent attention in public health because its prevalence reaches 50% worldwide and it can affect almost all age groups, including adolescents, adults, and the elderly. The prevalence of periodontal disease is predicted to be increasing annually because of the aging population growth, with periodontitis being more likely to occur in the elderly group. The high prevalence of periodontitis will increase the global burden, which has increased more than 50% from 11 years ago. This paper outlines how oral diseases such as periodontitis and periapical periodontitis may be linked to cardiovascular disease, atrial fibrillation and cardiac arrhythmia. We undertake a systematic review of the literature focused on acute dental infection and types of cardiac arrhythmia and also describe an illustrative case where an acute dental infection diagnosed as periapical periodontitis was associated with the occurrence of atrial fibrillation.

Keywords

Arrhythmia; chronic periodontitis; oral microbiome; atrial fibrillation

Cite This Paper

Chen Hong, Wenxian Fan, Mirigul·Mahsut, Madina·Abdullam, Nurjan·Wresdem, Merhaba·Yasen, Xinshang Li. Advances in the study of the effects of chronic periodontitis on cardiac arrhythmias. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 79-84. https://doi.org/10.25236/FMSR.2023.050811.

References

[1] Hindricks G, Potpara T, Dagres N, et al. The task force for the diagnosis and management of atrial fibrillation of the European society of cardiology (ESC) developed with the special contribution of the European heart rhythm association (EHRA) of the ESC [J]. Eur Heart (2021) 42:373–498. 

[2] Andrade J, Champagne J, Dubuc M, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation assessed by continuous monitoring: a randomized clinical trial[J]. Circulation. (2019) 140: 1779–88. 

[3] Miyauchi S, Tokuyama T, Shintani T, et al. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence[J]. J Cardiovasc Electrophysiol. (2021) 32:1240–50. 

[4] Madi M, Abuohashish HM, Attia D, et al. Association between periodontal disease and comorbidities in Saudi’s Eastern Province[J].  Biomed Res Int. (2021):5518195. 

[5] Nazir M, Al-Ansari A, Al-Khalifa K, et al.  Global prevalence of periodontal disease and lack of its surveillance [J]. Scientific World J 2020: 1–8. 

[6] Bui FQ, Almeida-da-Silva CLC, Huynh B, et al. Association between periodontal pathogens and systemic disease [J]. Biomed J. 2019, 42:27–35. 

[7] Zardawi F, Gul S, Abdulkareem A, Sha A. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited[J]. Front Cardiovasc Med. 2020, 7:625579. 

[8] Sen S, Redd K, Trivedi T, et al. Periodontal disease, atrial fibrillation and stroke[J]. Am Heart J. 2021, 235:36–43. 

[9] Muñoz Aguilera E, Suvan J, Orlandi M. Association between periodontitis and blood pressure highlighted in systemically healthy individuals: results from a nested case-control study[J]. Hypertension. 2021, 77:1765–74. 

[10] Tan J, Dai A, Pan L, et al. Inflamm-aging-related cytokines of IL-17 and IFN-γ accelerate osteoclastogenesis and periodontal destruction[J]. J Immunol Res 2021:9919024. 

[11] Surma S, Romanczyk M, Witalinska-Labuzek J. Periodontitis, blood pressure, and the risk and control of arterial hypertension: epidemiological, clinical, and pathophysiological aspects-review of the literature and clinical trials[J]. Curr Hypertens Rep. 2021, 23:1–14. 

[12] Xia X, Yue W, Chao B, et al. Prevalence and risk factors of stroke in the elderly in Northern China: data from the National Stroke Screening Survey[J]. J Neurol. 2019;266:1449–58. 

[13] Gnedovskaya E, Kravchenko M, Krotenkova M, Sergeeva A, Zagidullin T, Baydina E, Piradov M. White matter hyperintensity in middle-age adults (40–59 years) and risk factors for cerebrovascular disease[J]. Russ Neurol J. 2020;25:36–44. 

[14] Fagundes NCF, Almeida APCPSC, Vilhena KFB, Magno MB, Maia LC, Lima RR. Periodontitis as a risk factor for stroke: a systematic review and meta-analysis[J]. Vasc Health Risk Manag. 2019; 15: 519–32. 

[15] Sanz M, Marco Del Castillo A, Jepsen S, Gonzalez-Juanatey JR, D’Aiuto F, Bouchard P, et al. Periodontitis and cardiovascular diseases: consensus report[J]. J Clin Periodontol. 2020; 47: 268–88. 

[16] Abe M., et al. Close Association between Awareness of Teeth-Alignment Disorder and Systemic Disorders in Late Adolescence[J]. Healthcare (Basel, Switzerland) (2021), 9(4). 

[17] Abe M., et al. Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents[J]. Healthcare (Basel, Switzerland) (2020), 8(3). 

[18] Chang Y., et al. Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study[J]. European Journal of Preventive Cardiology (2020), 27(17): 1835-1845. 

[19] Dai L., et al. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation[J]. The Journal of Infectious Diseases (2020), 221(8): 1331-1341. 

[20] Du Z., et al. Prevalence of first-degree atrioventricular block and the associated risk factors: a cross-sectional study in rural Northeast China[J]. BMC Cardiovascular Disorders (2019), 19(1): 214. 

[21] Goette A. Is Periodontitis a Modifiable Risk Factor for Atrial Fibrillation Substrate [J]. JACC. Clinical Electrophysiology (2023), 9(1): 54-56. 

[22] Hassan A., et al. Atrial fibrillation and cardiac arrhythmia associated with acute dental infection: A systematic literature review and case report [J].  International Journal of Clinical Practice (2021), 75(5): e13875. 

[23] Heo S. C., et al. Virulence factors released from Porphyromonas gingivalis induce electrophysiological dysfunction in human pluripotent stem cell-derived cardiomyocytes[J]. Journal of Dental Sciences(2022), 17(4): 1559-1565. 

[24] Hsu P. -W., et al. Patients with periodontitis are at a higher risk of stroke: A Taiwanese cohort study [J]. Journal of the Chinese Medical Association: JCMA (2022), 85(10): 1006-1010. 

[25] Leelapatana P. and N. Limpuangthip. Association between oral health and atrial fibrillation: A systematic review [J]. Heliyon (2022), 8(3): e09161. 

[26] Miyauchi S., et al. Relationship Between Periodontitis and Atrial Fibrosis in Atrial Fibrillation: Histological Evaluation of Left Atrial Appendages[J]. JACC. Clinical Electrophysiology (2023), 9(1): 43-53. 

[27] Miyauchi S., et al. Periodontitis and the outcome of atrial fibrillation ablation: Porphyromonas gingivalis is related to atrial fibrillation recurrence[J]. Journal of Cardiovascular Electrophysiology (2021), 32(5): 1240-1250. 

[28] Miyauchi S., et al. Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates[J]. Heart and Vessels 2021, 36(11): 1721-1729. 

[29] Neumann F. A., et al. Mediterranean Diet and Atrial Fibrillation: Lessons Learned from the AFHRI Case-Control Study[J]. Nutrients 2022, 14(17). 

[30] Nezu T., et al. Assessment of Serum IgG Titers to Various Periodontal Pathogens Associated with Atrial Fibrillation in Acute Stroke Patients[J]. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association 2022, 31(3): 106301. 

[31] Oh S. E., N. S. Parikh. Recent Advances in the Impact of Infection and Inflammation on Stroke Risk and Outcomes[J]. Current Neurology and Neuroscience Reports 2022, 22(3): 161-170. 

[32] Struppek J., et al. Periodontitis, dental plaque, and atrial fibrillation in the Hamburg City Health Study [J]. PloS One, 2021, 16(11): e0259652. 

[33] Tashiro A., et al. Periodontitis was associated with worse clinical outcomes after catheter ablation for paroxysmal atrial fibrillation[J]. Frontiers In Cardiovascular Medicine 2022, 9: 1061243. 

[34] Zeng Z., et al. Assessing electrocardiogram changes after ischemic stroke with artificial intelligence [J]. PloS One 2022, 17(12): e0279706. 

[35] Zhang Z., et al. . Effects of Oral Inflammatory Diseases and Oral Hygiene on Atrial Fibrillation: A Systematic Review[J]. International Journal of Clinical Practice 2023: 1750981.