Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2019, 1(4); doi: 10.25236/FMSR.2019.010404.

Correlation between of Serum Uric Acid Level and Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction


Chu Xiaohui, Meng Junhong, Zhang HuilI, Zhang Yunxia

Corresponding Author:
Chu Xiaohui

Department of Neurology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832000, China


Objective To investigate the correlation between high uric acid level and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods Select our hospital 245 cases of acute cerebral infarction patients as the study subjects, record the patient's general information, according to the results of carotid artery colour to exceed divided into patches and plaques group, further divided into according to the nature of plaque unstable plaque group and stable plaque group, determination of patients with blood uric acid level, analysis with the correlation of carotid atherosclerotic plaques. Results: there were 212 patients in the plaque group and 33 patients in the non-plaque group. There were statistically significant differences between the two groups in age, history of diabetes and serum uric acid level (P<0.05). Multifactor logistic regression analysis showed that age, history of diabetes and serum uric acid were statistically significant (P<0.05). The serum uric acid level of the plaque group was significantly higher than that of the non-plaque group (P<0.05). Unstable plaque uric acid level> stable plaque group> no plaque group, with statistical significance (P<0.05). Conclusion The increase of serum uric acid level in patients with acute cerebral infarction is related to the occurrence of carotid atherosclerotic plaque, and is most closely related to unstable plaque.


Cerebral infarction; Carotid atherosclerotic plaque; Uric acid

Cite This Paper

Chu Xiaohui, Meng Junhong, Zhang HuilI, Zhang Yunxia. Correlation between of Serum Uric Acid Level and Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction. Frontiers in Medical Science Research (2019) Vol. 1 Issue 4: 18-22. https://doi.org/10.25236/FMSR.2019.010404.


[1] Zhang B, Yang N, Lin SP, et al (2017). Suitable concentrations of uric acid can reduce cell death in models of OGD and cerebral ischemia-reperfusion injury. Cell Mol Neurobiol, vol.37, no.5, pp.931-939.
[2] Yamada K, Kawasaki M, Yoshimura S, et al (2016). High&shy;intensity signal in carotid plaque on routine 3D&shy;TOF&shy;MRA is a risk factor of ischemic stroke. Cerebrovasc Dis, no.41, pp. 13-18.
[3] Song CF, Cai L, Wu LM, et al (2015). The study of correlation between serum uric acid level and carotid atherosclerosis in patients with cerebral infarction. Chin. J. Med, vol.50, no.9, pp.33-36.
[4] Liang ZG, Sun XW, Yang SW, et al (2018).Study on the level of serological indicators in acute ischemic stroke patients with carotid artery plaque. Journal of clinical neurology, vol.31, no.6, pp.425-428.
[5] Ooi YC, Gonzalez NR (2015). Management of extracranial carotid artery disease. Cardiol Clin, vol.33, no.1, pp. 1-35.
[6] Li XP (2016). Changes of serum visfatin content in patients with acute cerebral infarction and its influence on carotid atherosclerotic plaque formation and stability. Chinese Journal of Practical Neurology, vol.19, no.3, pp.103-104.
[7] Saba L, Saam T, Jäger HR, et al (2019). Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications.Lancet Neurol, vol.18, no.6, pp.559-572.
[8] Feig DI, Kang DH, Johnson RJ (2008). Uric acid and cardiovascular risk. N Engl J Med, vol. 359, no.17, pp.1811-1821.
[9] Ji W, Zhu Y, Kan P, et al (2017). Analysis of intestinal m icrobial communities of cerebral infarction and ischem ia patients based on high throughput sequencing technology and glucose and lipid m etabolism .M ol M ed Rep, vol.16, no. 4, pp.5413-5417.