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Frontiers in Medical Science Research, 2019, 1(4); doi: 10.25236/FMSR.2019.010406.

Recovery of platelet count in patients with liver primary carcinoma after hepatectomy and its clinical significance


Hou Jiaying 1, Li lin2, Liu Qinghua 1*

Corresponding Author:
Liu Qinghua

1 Department of Oncology, The First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi 832000, China  
2 Production and Construction Corps Hospital, Wulumuqi 830000, China
*Corresponding Author


Objective: To analyze platelet count after resection of liver primary carcinoma and its clinical significance. Methods: This study is a retrospective analysis of the clinical data of 128 patients with liver primary carcinoma who underwent hepatectomy in the Department of Hepatobiliary Surgery, Medical School the First Affiliated Hospital of  School of Medicine, Shihezi University from August 20 to August 2019.According to platelet count levels (PLT),  the patients were grouped on the first day after surgery, platelet counts <100×109/L were divided into low platelet groups, normal groups at 100-300×109/L, and correlation between platelet count and postoperative liver failure was analyzed for a diagnostic value. Results: Among the 128 patients, 35 of them were grouped as with low platelet counts on the first day after surgery, and the other 93 patients were normal. There were 20 cases of liver failure within six months after the patient underwent surgery.In the single factor analysis of liver failure, the age of  liver failure group, the PLT value one day after surgery and the preoperative liver function B grade were higher than the non-hepatic failure group, the difference was statistically significant (P>0.05); In the multivariate analysis, both the PLT count on the first postoperative day and the preoperative liver function grading are independent risk factors for the complications of hepatic failure after hepatectomy. The PLT count on the first day after surgery has a good predictive value for hepatic failure after liver carcenoma complications. The ROC curve was drawn. When the Jordan count was 0.431, the sensitivity and specificity were 0.60 and 0.83 respectively. The area AUC=0.753 (0.651 to 0.854). Conclusion: Age and postoperative PLT count and preoperative liver function were important pathogenic factors for liver failure after hepatectomy. Platelet count has diagnostic value for predicting liver failure after resection of primary liver carcinoma.


Primary liver carcinoma; Platelet count Clinical significance Diagnostic value

Cite This Paper

Hou Jiaying, Li lin, Liu Qinghua. Recovery of platelet count in patients with liver primary carcinoma after hepatectomy and its clinical significance. Frontiers in Medical Science Research (2019) Vol. 1 Issue 4: 35-43. https://doi.org/10.25236/FMSR.2019.010406.


[1] Deng Xiangping, Mao Xiaoxue, Zhao Bin, et al (2018). Recovery and clinical significance of platelet count in patients with primary liver carcinoma after resection. Journal of Integrated Traditional and Western Medicine on Liver Diseases, vol.28, no. 3, pp.51-53.
[2] Niu Guohao, Gao Liwei, Qian Junxi, et al (2018). Changes in platelet activation, hemorheology and hyperthyroid microcirculation in patients with primary liver carcinoma. Laboratory and Test Medicine, no.2, pp.234-236.
[3] Xu Wei, Wei Xinhuan, Lin Wei, et al (2018). Clinical significance of platelet count and its dynamic changes in patients with chronic acute liver failure. Journal of Clinical Hepatology, vol.34, no.4, pp.12-13.
[4] Li Yingjie, Kong Xianbing (2019). Influencing factors and preoperative evaluation of liver failure after partial hepatectomy. Medical Information, no.3, pp. 37-41.
[5] Zhanbo W U, Zhao N, Shen X, et al (2017). Correlation of PET/CT SUVmax with infiltration level of immune cells in patients with non-small cell lung carcinoma and its clinical significance.Chinese Journal of Clinical Oncology.
[6] Deng Liping, Cheng Ruiwen, Li Qiuguo, et al (2017). Argon-helium cryoablation for the treatment of platelet count changes in patients with advanced primary liver carcinoma. Chinese General Practice.
[7] Cheng Houpi, Lan Jun (2017). Clinical significance of coagulation, fibrinolysis and platelet changes in patients with primary liver carcinoma before and after interventional therapy. Thrombosis and Hemostasis, vol.23, no.4, pp. 656-658.
[8] Jo H S, Kim D S, Jung S W, et al (2018). Clinical significance of post-hepatectomy hepatic failure in patients with liver metastases from colorectal cancer..Annals of Hepato-Biliary-Pancreatic Surgery, vol. 22, no.2, pp.93-.94.
[9] Tang Yufu, Jiang Xiaofeng, Zhao Yu, et al (2010). Causes and prevention of hemorrhage after liver carcinoma with microwave ablation. Chinese Journal of General Basic and Clinical Medicine, no.12, pp.1294-1298.
[10] Ma Liyan, Sun Zhaohui, Hang Jianfeng (2011). Clinical significance of changes in coagulation parameters and platelet parameters in patients with primary liver carcinoma. South China Journal of National Defence Medicine, no.4, pp. 330-331+334.
[11] Fukui N, Golabi P, Otgonsuren M, et al (2018). Hospice care in Medicare patients with primary liver cancer: the impact on resource utilisation and mortality.Alimentary Pharmacology & Therapeutics, vol.47, no.5, pp.680-681.
[12] Ding Xinshu (2018). Prognostic risk factors in patients with primary liver carcinoma undergoing surgical resection. China Health Standards Management, vol. 8, no.13, pp. 80-81.