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Frontiers in Medical Science Research, 2023, 5(8); doi: 10.25236/FMSR.2023.050814.

Latest Research Advances in Paget's Disease of Bone


Wanjing Zhai1, Zhankui Wang1, Shilei Qin2, Pengfei Han3, Yunfeng Xu2,4

Corresponding Author:
Yunfeng Xu

1Department of Graduate School, Graduate Student Department of Changzhi Medical College, Changzhi, Shanxi, 046000, China

2Department of Orthopaedics, Changzhi Yunfeng Hospital, Changzhi, Shanxi, 046000, China

3Department of Orthopedics, Heping Hospital of Changzhi Medical College, Changzhi, 046000, China

4Changzhi Spinal Disease Research Institute, Changzhi, Shanxi, 046000, China


Paget's disease of bone (PDB) is a non-inflammatory, metabolic skeletal disease. It is characterized by excessive bone resorption and irregular bone reconstruction. Its onset is often associated with both genetic and environmental factors. PDB is characterized by a very distinct geographical distribution, being more common in Western countries and rarer in Asia. The most significant susceptibility gene at the moment is SQSTM1. The imbalance between osteoclasts and osteoblasts is the main mechanism of its pathogenesis. The pelvis, spine, skull, femur, and tibia are most commonly involved, with less involvement in the upper limbs, clavicle, ribs, and scapula. It is less common before the age of 40, is predominantly male, and has a positive correlation between age and incidence. Pain and bone deformities are common manifestations of PDB. The diagnosis of PDB depends on imaging and biochemical markers. For the detection of PDBs, radionuclide bone scan is a more accurate test. Bisphosphonates are currently the leading therapeutic agent, and it has been shown that intravenous zoledronate provides remission in most patients and can prevent disease progression. In recent years, the number of related cases in China has gradually increased. The article summarizes relevant literature and analyzes relevant progress in order to provide help in the diagnosis and treatment of PDB.


Paget disease of bone; Bisphosphonate; Diagnosis; Treatment

Cite This Paper

Wanjing Zhai, Zhankui Wang, Shilei Qin, Pengfei Han, Yunfeng Xu. Latest Research Advances in Paget's Disease of Bone. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 101-107. https://doi.org/10.25236/FMSR.2023.050814.


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