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Frontiers in Medical Science Research, 2023, 5(8); doi: 10.25236/FMSR.2023.050815.

Research progress of curcumin in anti-tumor effect


Yong Ou1, Na Gu2, Kang Cai1, Xu Chao3

Corresponding Author:
Xu Chao

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

2Nanzheng District People's Hospital, Hanzhong, Shaanxi, 723100, China

3The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China


Curcumincumin is the main active component of the rhizoma Curcumincuma longa, a hydrophobic polyphenol with a wide range of biological and pharmacological activities. It can be used to treat tumors, diabetes, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome and liver diseases, etc. This article reviews the anti-tumor effects and mechanisms of Curcumincumin, such as targeted regulation of tumor cell cycle, inhibition of angiogenesis, and promotion of tumor cell apoptosis and other related signaling pathways and targets. It is hoped to provide some reference for the clinical research and application of Curcumincumin in anti-tumor in the future.


Curcumin; Esophageal carcinoma; Anticancer properties; Research progress

Cite This Paper

Yong Ou, Na Gu, Kang Cai, Xu Chao. Research progress of curcumin in anti-tumor effect. Frontiers in Medical Science Research (2023) Vol. 5, Issue 8: 108-114. https://doi.org/10.25236/FMSR.2023.050815.


[1] KOCAADAM B, ŞANLIER N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health [J]. Crit Rev Food Sci Nutr, 2017, 57(13): 2889-95.

[2] Cui Yuhan, An Xiao, Wang Haifeng, et al. Study on chemical components of Curcumincuma longa [J]. Chinese Herbal Medicine, 2016, 47(7): 1074-1078. 

[3] Kunnumakkara AB, Bordoloi D, Padmavathi G, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases[J]. Br J Pharmacol, 2017, 174( 11) : 1325-1348. 

[4] Kuttan R, Kuttan G. Inhibituon of lung metasis in mice induced by BI6F10 melanoma calls polyphenolic compounds [J]. Cancer Lett, 1985, 29:197. 

[5] Xiao Xuyang, Wang Xiaodong. Research progress on the anti-tumor mechanism of Curcumin [J]. Journal of Jinzhou Medical College, 2006, 27 (1): 56-58. 

[6] Duan Jinqi, Zhang Linxi. Research progress of anti-tumor mechanism of Curcumin [J]. Jiangsu Medicine, 2011, 27 (15): 1824-1826. 

[7] Aggarwal B B, Sung B. Pharmacological basis for the role of Curcumin in chronic diseases: an age - old spice with moderntargets [J]. Trends Pharmacol Sci, 2009, 30(2): 85 -94. 

[8] Osorio-Tobón J F, Carvalho P I, Barbero G F, et al. Fast analysis of Curcuminoids from turmeric (Curcumincuma longa L. ) by high-performance liquid chromatography using a fused-core column [J]. Food Chem, 2016, 200: 167-74. 

[9] Cui Minghua, Fu Erhua, Lin Zhenhua, Park Yong-shi. Research progress of anti-tumor pharmacological effects of Curcumin [J]. Chinese Journal of Clinical Pharmacology, 2021, 37(02):186-188+196. 

[10] Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics2020: Globocan estimates of incidence and mortalityworldwide for 36 cancers in 185 countries [J]. CA CancerJ Clin, 2021, 71(3): 209-249. 

[11] Tian Tongde, YUE Liyun, Tian Tongliang, et al. Relationship between tumor inflammatory microenvironment and immunity and intervention strategy of traditional Chinese medicine [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 58(3):209-213. 

[12] Xu Ming, Lu Jiahui. Pathogenesis and treatment of malignant tumor from phlegm, blood stasis and poison [J]. International Journal of Traditional Chinese Medicine and Chinese Materia Medica, 2016, 38(11): 1028-1029. 

[13] Ling Changquan, Yue Xiaoqiang, Ling Chen. Threeadvantages of using traditional Chinese medicine to preventand treat tumor [J]. Journal of Integrative Medicine, 2014, 12(4):331-335. 

[14] Lin Yuanxiong. Effect of Curcumin on the proliferation and cell cycle of nasopharyngeal carcinoma CNE-1 cells [J]. Journal of Qiqihar Medical College, 2010, 31(12):1855-1856. 

[15] Wang Guiqiu. The effect of Curcumin on the apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z and its mechanism [J]. Journal of Practical Medicine & Clinic, 2013, 16(12):1126-1129. 

[16] Chen J. Effects of Curcumin on proliferation and invasion of nasopharyngeal carcinoma by regulating Tiam1 protein expression [J]. Journal of Central South Medical Science, 2019, 47(5):483-507. 

[17] Jin H, Qiao F, Wang Y, et al. Curcumin inhibits cell proliferation andinduces apoptosis of human non - small cell lung cancer cells throughthe upregulation of miR - 192 - 5p and suppression of PI3K / Akt sig-naling pathway[J]. Oncology reports, 2015, 34(5): 2782 - 2789. 

[18] Chen Shi, Li Dechuan, Liu Hua. Apoptosis of human lung cancer cells induced by Curcumin and its mechanism [J]. Journal of Wuhan University: Medical Edition, 2012, 33 (4) : 507-510. 

[19] Xu Y, Zhang J, Han J, et al. Curcumin inhibits tumor proliferation in-duced by neutrophil elastase through the upregulation of α1 - antitryp-sin in lung cancer[J]. Molecular oncology, 2012, 6( 4) : 405 - 417. 

[20] Jiang J, Cao Y D, Mo Na, et al. Curcumin inhibits A549 cell proliferation through P53 /P21 /PCNA/eI F4E signaling pathway [J]. Journal of the Third Military Medical University, 2012, 34 (1) : 49-53. 

[21] He Qiuxia, HOU Hailong, Yuan Yanqiang, et al. Effects of Curcumin on proliferation and apoptosis of lung adenocarcinoma A549 cells [J]. Chin J Traditional Chinese Medicine, 2010, 28 (10) : 2130-2132. 

[22] Li Ziguang, Wang Enju, Liu Zhaoyang, et al. The role of ERK1/2 in the inhibitory effect of Curcumin on the proliferation of lung cancer A549 cells [J]. Journal of Bengbu Medical College, 2011, 36 (3) : 231-234. 

[23] Liu X, Sun K, Song A, et al. Curcumin inhibits prolif-eration of gastric cancer cells by impairing ATP-sensitivepotassium channel opening [J]. World J Surg Oncol, 2014, 12: 389. 

[24] Ji J, Wang H S, Gao Y Y, et al. Synergistic anti-tumoreffect of KLF4 and Curcumin in human gastric carcinomacell line[J]. Asian Pac J Cancer Prev, 2014, 15( 18) :7747-7752. 

[25] Chen X, Chen X, Zhang X, et al. Curcuminoid B63 in-duces ROS-mediated paraptosis-like cell death by targe-ting TrxR1 in gastric cells[J]. Redox Biol, 2019, 21: 101061. 

[26] Zhou X, Wang W, Li P, et al. Curcumin enhances theeffects of 5-Fluorouracil and oxaliplatin in inducing gas-tric cancer cell apoptosis both in vitro and in vivo[J]. Oncol Res, 2016, 23( 1-2) : 29-34. 

[27] Yang Weili, Yang Rongping, Luo Yongsheng, et al. Clinical analysis of Curcumin combined with FOLFOX regimen in the treatment of advanced gastric cancer [J]. Journal of Inner Mongolia Medical University, 2019, 12 (1): 96-99. 

[28] Shastri A A, Saleh A, Savage J E, et al. Dietary alterations modulate the microRNA 29/30 andIGF-1/Akt signaling axis in breast cancer livermetastasis[J]. Nutr Metab(Lond), 2020, 3(17):23-043. 

[29] Chen C P, Xu Q, Zhao H F. Intervention effect of Curcumin on the expression of miR-29 and VEGF in hepatocellular carcinoma cells [J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2020, 30 (10) : 785-790, 869. 

[30] Chen S, Yang C, Sun C, et al. miR-21-5psuppressed the sensitivity of hepatocellular carcinomacells to cisplatin by targeting FASLG[J]. DNA CellBiol, 2019, 38(8):865-873. 

[31] Li J, Wei H, Liu Y, et al. Curcumin inhibitshepatocellular carcinoma via regulating miR-21/TIMP3 axis[J]. Evid Based Complement AlternatMed, 2020, 7(17):2892-917. 

[32] Zhou C, Hu C, Wang B, et al. Curcuminsuppresses cell proliferation, migration, and invasionthrough modulating miR-21-5p/SOX6 axis inhepatocellular carcinoma [J]. Cancer Biother Radiopharm, 2020, 8(4):37-34. . 

[33] Fang L, Zhou J, Xie H, et al. Effects of Curcumin on cell proliferation, cell cycle distribution and CyclinD1 gene expression in human colon cancer HT-29 cells [J]. Chongqing Med, 2016, 45(32): 4479-4481. 

[34] Mudduluru G, George-William JN, Muppala S, et al. Curcumin regulates miR-21expression and inhibits invasion and metastasis in colorectal cancer[J]. Bioscience Reports, 2011, 31(3): 185-197

[35] Tuorkey M. Curcumin a potent cancer preventive agent: Mechanisms of cancer cellkilling[J]. Interventional Medicine and Applied Science, 2014, 6(4): 139-146. 

[36] Luo Qiang, Sun Li, Zhang Zhang, et al. Effect of Curcumin on apoptosis of human colon cancer SW620 cells [J]. Chinese Journal of Gerology, 2011, 31(16): 3108-3109. 

[37] Zhang Z, Chen H, Xu C, et al. Curcumin inhibits tumor epithelial‑mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells [J]. Oncol Rep, 2016, 35(5): 2615-23. 

[38] Seo J A, Kim B, Dhanasekaran D N, et al. Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells [J]. Cancer Lett, 2016, 371 (1): 30-7. 

[39] Liu L D, Pang Y X, Zhao X R, et al. Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells [J]. Arch Gynecol Obstet, 2019, 299(6): 1627-39. 

[40] Weir N M, Selvendiran K, Kutala V K, et al. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK [J]. Cancer Biol Ther, 2007, 6(2): 178-84. 

[41] Kumar D, Basu S, Parija L, et al. Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells. Biomed Pharmacother, 2016, 8(1):31-37. 

[42] Fan Shizhen, Chen Xuna, Yu Bohai, et al. Curcumin promotes autophagy in SiHa cells by inhibiting PI3K/Akt/mTOR. Chin J Lab Diagnostics, 2017, 5 (21): 897-900. 

[43] YANG S, LIN S, LI N, et al. Burden, trends, and risk factors of esophageal cancer in China from 1990 to 2017: an up-to-date overview and comparison with those in Japan and South Korea [J]. J Hematol Oncol, 2020, 13(1): 14-6. 

[44] Li X J, LUO Q, Sun L, et al. Effects of Curcumin on proliferation and PTEN/PI3K/Akt signaling pathway of esophageal cancer Ec109 cells [J]. Chin J Applied Physiology, 2015, 31(05): 465-8. 

[45] Lin M L, Lu Y C, Chen H Y, et al. Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by Curcumin inhibits SDF-1α-induced invasion of human esophageal carcinoma cells [J]. Mol Carcinog, 2014, 53(5): 360-79. 

[46] Chen Jianhua. The effect of Curcumin on the proliferation and Wnt signaling pathway of esophageal cancer cell line Eca-109 [D]; Hebei Medical University, 2015. 

[47] Zhao W, Zhou X, Qi G, et al. Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation [J]. J Biochem Mol Toxicol, 2018, 32(5): e22049. 

[48] Liu T, Chi H, Chen J, et al. Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR [J]. Gene, 2017, 63(1): 29-38. 

[49] Gong X, Jiang L, Li W, et al. Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression [J]. Bioengineered, 2021, 12(1): 5017-27. 

[50] Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT [J]. Oncol Rep, 2021, 45(4). 79-62. 

[51] Hu C, Li M, Guo T, et al. Anti-metastasis activity of Curcumin against breast cancer via the inhibition of stem cell-like properties and EMT [J]. Phytomedicine, 2019, 58(12): 1527-40. 

[52] Shi J, Wang Y, Jia Z, et al. Curcumin inhibits bladder cancer progression via regulation of β-catenin expression [J]. Tumour Biol, 2017, 39(7): 1770-2548. 

[53] Bharti A C, Donato N, Singh S, et al. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis [J]. Blood, 2003, 101(3): 1053-62.