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Academic Journal of Medicine & Health Sciences, 2023, 4(9); doi: 10.25236/AJMHS.2023.040911.

Exploration of the mechanism of MMPs for ECM in KBD cartilage


Zirong Zhou1, Jiushe Kou2

Corresponding Author:
Jiushe Kou

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2The Second Afiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China


In KBD, cartilage extracellular matrix (ECM) destruction and abnormal homeostasis are gaining increasing attention as therapeutic targets for cartilage regeneration. Moreover, during the progression of KBD, the cartilage ECM showed significant pathological changes, which may be a research-meaningful biomarkerfor identifying the pathological stage of KBD. In this review, we summarize the abnormal ECM, the role of homeostasis in articular cartilage during KBD, and the association of ECM with other relevantfactors. Furthermore, we provide the cartilage ECM-related factors and their interrelationships.


Kashin-beck disease; cartilage; ECM; MMPs; TIMPs

Cite This Paper

Zirong Zhou, Jiushe Kou. Exploration of the mechanism of MMPs for ECM in KBD cartilage. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 9: 69-77. https://doi.org/10.25236/AJMHS.2023.040911.


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