Colorectalcancer (CRC), with its high incidence and high mortality, has been a popular topic of research in China in recent years. At present, the treatment of CRC mainly includes surgery, radiotherapy and chemotherapy, molecular targeted therapy, and immunotherapy. Traditional Chinese medicine has unique advantages in reducing toxicity and increasing efficiency, improving patients' quality of life, and prolonging survival time. In this paper, the research progress of Chinese and western medicine treatment of CRC was reviewed in recent years, in order to provide positive reference for clinical treatment.

Liu Lei, Quan Jianfeng, Zhang Peiyun. Research Progress of Chinese and Western Medicine in the Treatment of CRC. Frontiers in Medical Science Research (2023) Vol. 5, Issue 9: 120-126. https://doi.org/10.25236/FMSR.2023.050920.

[1] Li Lingchang. A multi-center, randomized, double-blind controlled study of Fufangchangtai granule in the treatment of colon cancer [D]. Nanjing University of Chinese Medicine, 2019. 

[2] Wang Guojun, Gao Chunfang. Laparoscopic Total Mesorectal Excision of Rectal Cancer [J]. Chinese Journal of Bases and Clinics in General Surgery, 2011, 18(01):92-94. 

[3] Zheng Minhua, Hu Yanyan, Lu Aiguo, et al. Clinical comparison of laparoscopic and open total mesorectal excision for lower rectal cancer [J]. Chinese Journal of Gastrointestinal Surgery, 2004(03):177-180. 

[4] Zhang Xubing, Wu Qingbin, Gu Chaoyang, et al. Hand-assisted laparoscopic surgery versus conventional open surgery in intraoperative and postoperative outcomes for colorectal cancer: An updated systematic review and meta-analysis [J]. Medicine, 2017, 96(33):e7794. 

[5] Stănciulea Oana, Eftimie Mihai, Moşteanu Iulian, et al. Minimally Invasive Colorectal Surgery - Present and Future Trends [J]. Chirurgia (Bucharest, Romania: 1990), 2019, 114(2):167-173. 

[6] Shi Wenjing. Research on the effect and mechanism of Xiao'ai Jiedu Decoction on colon cancer [D]. Nanjing University of Chinese Medicine, 2018. 

[7] He Sijia, Huang Qian, Li Qi. Progress on chemotherapy and targeted therapy in metastatic colorectal cancer [J]. World Clinical Drugs, 2020, 41(11):844-849. 

[8] Hou Xiaoru. Analysis of neoadjuvant simple radiotherapy and neoadjuvant concurrent radiotherapy and chemotherapy for locally advanced rectal cancer [J]. China Practical Medicine, 2012, 7(21):121-122. 

[9] Rana Nitesh, Chakravarthy A Bapsi, Kachnic Lisa A, et al. Neoadjuvant Treatment for Locally Advanced Rectal Cancer: New Concepts in Clinical Trial Design [J]. Current treatment options in oncology, 2017, 18(2):13. 

[10] Xu Yuying. Analysis of the Characteristics and Gene Mutation Trends of Traditional Chinese Medicine Dominant Population in 68 Cases of Advanced Colorectal Cancer in the Real World [D]. Beijing University of Chinese Medicine, 2018. 

[11] Xie Lin, Gao Huibing. The Efficacy and Safety of Pembrolizumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer [J]. The Journal of Evidence-Based Medicine, 2020, 20(04):213-216. 

[12] André Thierry, Tougeron David, Piessen Guillaume, et al. Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability-High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study [J]. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023, 41(2):255-265. 

[13] Smith Kortnye Maureen, Desai Jayesh. Nivolumab for the treatment of colorectal cancer [J]. Expert review of anticancer therapy, 2018, 18(7):611-618. 

[14] Casak Sandra J, Marcus Leigh, Fashoyin Aje Lola, et al. FDA Approval Summary: Pembrolizumab for the first-line treatment of patients with MSI-H/dMMR advanced unresectable or metastatic colorectal carcinoma [J]. Clinical cancer research: an official journal of the American Association for Cancer Research, 2021, 27(17):0557. 

[15] Overman Michael J., Bergamo Francesca, McDermott Raymond S., et al. Nivolumab in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC): Long-term survival according to prior line of treatment from CheckMate- 142 [J]. Journal of Clinical Oncology, 2018, 36(4):554-554. 

[16] Rodríguez-Ruiz M E, Perez-Gracia J L, Rodríguez I, et al. Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients [J]. Annals of oncology: official journal of the European Society for Medical Oncology, 2018, 29(5):1312-1319. 

[17] Javier Rodriguez, Eduardo Castañón, Jose Luis Perez Gracia, et al. A randomized phase II clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis [J]. Journal for ImmunoTherapy of Cancer, 2018, 6(1):1-7. 

[18] Zhu Jianping. Meta analysis of the therapeutic effect of traditional Chinese medicine combined with chemotherapy on colon cancer [D]. Gansu University of Traditional Chinese Medicine, 2016. 

[19] Wang Jing. Clinical Study on Postoperation of Colon Cancer which was type of pi xu shi sheng Was treated by peishijianpiyichang decoction Combined with FOLFOX Chemotherapy [D]. Gansu University of Chinese Medicine, 2017. 

[20] Zhao Changlin, Peng Linji, Zhang Zili, et al. Effect of acupuncture on the activity of the peripheral blood T lymphocyte subsets and NK cells in patients with colorectal cancer liver metastasis [J]. Chinese Acupuncture & Moxibustion, 2010, 30(01):10-12. 

[21] Qu Yuanyuan, Yang Xinzhong. Treatment of 30 Cases of Postoperative Intestinal Obstruction of Colon Cancer with External Application of Traditional Chinese Medicine [J]. Jilin Journal of Traditional Chinese Medicine, 2016, 26(2):31-32. 

[22] Qin Dongli, Song Yifan. Clinical analysis of Boerning capsule combined with FOLFOX4 regimen in the treatment of colon cancer [J]. Guide of China Medicine, 2013, 11(27):214-215. 

[23] Shen Jiawen, Luo Hui, Ning Ni, et al. Pharmacological Effects of Traditional Chinese Medicine Treatment on Colon Cancer in Recent Years [J]. Chinese Archives of Traditional Chinese Medicine, 2017, 35(10):2544-2546. 

[24] Zhang Lina. Effect of Jianpi Fuzheng Soup on Survival of Middle-late Colorectal Canner [D]. Guangxi Medical University, 2015.

[25] Hu Hongxia. The Clinical Effect of Shenling Baishu in Rehabilitation of Gynecological Surgery [J]. China & Foreign Medical Treatment, 2017, 36(28):22-24.