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Frontiers in Medical Science Research, 2023, 5(10); doi: 10.25236/FMSR.2023.051001.

Research progress on reducing cognitive impairment under high-altitude hypoxia conditions by improving sleep awakening cycle through nasal insulin pretreatment


Huang Qingqing1, Zeng Jingzheng1, Lin Lu1, Dai Xuemei1, Shi Qin2, Wu Xiao2, Gong Gu1

Corresponding Author:
Gong Gu

1Department of Anesthesiology, General Hospital of Western Theater Command, Chengdu, Sichuan, 610083, China

2Department of Anesthesiology, North Sichuan Medical College, Nanchong, Sichuan, 637000, China


The special geographical environment and climate characteristics of the plateau can have many impacts on human physiology and psychology, and in severe cases, it can also endanger life and health. Previous studies have shown that as altitude increases, problems such as sleep disorders, changes in brain function, and anxiety continue to emerge among officers and soldiers stationed at high altitudes. Among them, sleep disorders and cognitive impairment are two particularly prominent issues, which have received much attention from military occupational medicine. Cognitive impairment (CI) often coexists with sleep disorders and is highly destructive, directly affecting the combat effectiveness of the military. Therefore, prevention and treatment measures can be sought to improve sleep disorders and cognitive impairment caused by altitude hypoxia through intervention. Existing research has clearly shown that enhancing the insulin effect of the central nervous system can improve learning and memory functions in both animals and humans, especially hippocampus dependent (declarative) memory. After intranasal administration of insulin, it can bypass the blood-brain barrier, pass through the extracellular nerve gap of the trigeminal nerve and the olfactory nerve pathway, and quickly reach the central nervous system through paracellular transport and endocytosis, increasing the central insulin concentration distributed in the space around cerebral blood vessels. It inhibits the secretion of the hypothalamic pituitary adrenal axis by acting on the hypothalamic nucleus and marginal structures (such as the hippocampus) that can express a large number of insulin receptors, improving sleep cycle disorders and cognitive impairment. This article will provide a review of nasal insulin, sleep awakening cycle, and cognitive impairment.


cognitive impairment, high-altitude, hypoxia, sleep awakening cycle, nasal insulin

Cite This Paper

Huang Qingqing, Zeng Jingzheng, Lin Lu, Dai Xuemei, Shi Qin, Wu Xiao, Gong Gu. Research progress on reducing cognitive impairment under high-altitude hypoxia conditions by improving sleep awakening cycle through nasal insulin pretreatment. Frontiers in Medical Science Research (2023) Vol. 5, Issue 10: 1-7. https://doi.org/10.25236/FMSR.2023.051001.


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