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Frontiers in Medical Science Research, 2023, 5(10); doi: 10.25236/FMSR.2023.051008.

Prediction of the Mechanism of Jinlingzi Powder in the Intervention of Gastric Cancer Based on Transcriptomics and Network Pharmacology


Liyao Chen, Yiqiang Liu, Ying Wu, Cuixian Wu, Yan Qin, Peng Wu

Corresponding Author:
Liyao Chen

The Second People's Hospital of Jiangyou, Mianyang, Sichuan, 621701, China


Traditional Chinese medicine (TCM) has unique advantages in alleviating gastric cancer (GC), and Jinlingzi Powder is a common drug used in TCM treatment. However, the potential mechanism for its treatment of GC is unclear. The purpose of this study is to integrate transcriptomics, network pharmacology and molecular docking to investigate the active components and targets of Jinlingzi Powder's intervention in GC and related pathways, in order to provide a basis for further revealing its mechanism of action and developing Jinlingzi Powder. We obtained the potential targets of Jinlingzi Powder and GC-related genes from public database. Then we identified and visualized Potential targets and signaling pathways through bioinformatics analysis, including protein-protein interaction (PPI), Gene Ontology (GO) functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Subsequently, molecular docking was performed to further validate these findings. Resultly, the results showed that potential targets including IL6, PTGS2, MMP9, HMOX1, MYC, CHRM3, TOP2A, CA2, and KCNMA1 were the therapeutic targets of Jinlingzi Powder for gastric cancer. The functional enrichment analysis indicate that through synergistically regulating some biological pathway, such as inflammatory response, cellular response to tumor necrosis factor, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, TNF signaling pathway, MicroRNAs in cancer, Pathways in cancer, etc. , which have therapeutic effects on gastric cancer. In addition, the molecular docking results showed that the compounds had good binding activity to the action target in vivo. In Conclusion, this study comprehensively describes the potential targets and molecular mechanisms of Jinlingzi Powder for the treatment of gastric cancer. It also provides promising avenues for revealing the treatment of diseases by TCM through scientific basis and therapeutic mechanisms.


IBS-D; Tongxie Yaofang; Sijunzi Decoction; Meta-analysis

Cite This Paper

Liyao Chen, Yiqiang Liu, Ying Wu, Cuixian Wu, Yan Qin, Peng Wu. Prediction of the Mechanism of Jinlingzi Powder in the Intervention of Gastric Cancer Based on Transcriptomics and Network Pharmacology. Frontiers in Medical Science Research (2023) Vol. 5, Issue 10: 49-62. https://doi.org/10.25236/FMSR.2023.051008.


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