Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2023, 5(10); doi: 10.25236/FMSR.2023.051010.

Exploration on the Role and Mechanism of Chronic Inflammation on Polycystic Ovary Syndrome Based on Blood-Water Homoeopathy in Chinese Medicine

Author(s)

Yuejiao Wang1, Xinchun Xiao2, Xiaoping Cui2, Xia Liu2

Corresponding Author:
Xinchun Xiao
Affiliation(s)

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Abstract

Polycystic ovary syndrome (PCOS), as a common gynaecological disease, has a variety of clinical manifestations and a lingering course. Modern medicine believes that chronic low-grade inflammation is involved in the development of PCOS, and the abnormal coagulation/fibrinolytic function of PCOS patients will aggravate and prolong the development of the disease. Chinese medicine believes that the basic pathogenesis of this disease lies in kidney deficiency, with qi, phlegm, and stasis as pathological products, which is the same as the pathogenesis analysed by modern medicine, and corresponds to the idea of treating blood and water together. Therefore, it is of great significance to summarize and elucidate the pathogenic mechanism of PCOS in both Chinese and Western medicine, and combine it with the theory of "if the blood is not favourable, then the water will be water" for the development of subsequent related research and clinical treatment. Therefore, summarising and elucidating the pathomechanisms of PCOS in Chinese and Western medicine, combined with the theory of "if the blood is not favourable, then the water will become water", is of great significance to the subsequent research and development of clinical treatment.

Keywords

PCOS; chronic inflammation; coagulation/fibrinolytic function; blood is not favourable to water

Cite This Paper

Yuejiao Wang, Xinchun Xiao, Xiaoping Cui, Xia Liu. Exploration on the Role and Mechanism of Chronic Inflammation on Polycystic Ovary Syndrome Based on Blood-Water Homoeopathy in Chinese Medicine. Frontiers in Medical Science Research (2023) Vol. 5, Issue 10: 70-76. https://doi.org/10.25236/FMSR.2023.051010.

References

[1] Ruan Xiangyan, Li Meng, Alfred O Mueck. Why does polycystic ovary syndrome (PCOS) need Long-term management? [J]. Curr Pharm Des, 2018, 24(39):4685-4692. 

[2] Tan Wei, Zhang Jie, Dai Fangfang, et al. Insights on the NF-κB system in polycystic ovary syndrome, attractive therapeutic targets [J]. Molecular and cellular biochemistry, 2023: 1-20. 

[3] Zhang Shun, Tu Haoyan, Zhu Jiamin, et al. Dendrobium nobile Lindl. Polysaccharides improve follicular development in PCOS rats [J]. International Journal of Biological Macromolecules, 2020, 149:826-834. 

[4] Ni Xiaorong, Sun Zhoujun, Hu Guohua, et al. High Concentration of Insulin Promotes Apoptosis of Primary Cultured Rat Ovarian Granulosa Cells Via Its Increase in Extracellular HMGB1 [J]. Reproductive Sciences, 2015, 22(3):271-277.

[5] Oróstica L, Astorga I, Plaza-Parrochia F, et al. Proinflammatory environment and role of TNF-α in endometrial function of obese women having polycystic ovarian syndrome [J]. International journal of obesity (2005), 2016, 40(11):1715-1722. 

[6] Zeev Blumenfeld. The Possible Practical Implication of High CRP Levels in PCOS [J]. Clinical Medicine Insights: Reproductive Health, 2019, 13:1179558119861936. 

[7] Bannigida Doddappa M, Nayak B Shivananda, Vijayaraghavan R, et al. Insulin resistance and oxidative marker in women with PCOS [J]. Archives of physiology and biochemistry, 2020, 126(2): 183-186. 

[8] Zhao Wenhui. Clinical Efficacy of Bushen Huoxue Treatmentand Blood Stasis PCOS on Kidney Deficiency and its Effect on Serum Endocrine and CRP Levels [D]. Shandong University of Chinese Medicine, 2021. 

[9] Zeev Blumenfeld. The Possible Practical Implication of High CRP Levels in PCOS [J]. Clinical Medicine Insights: Reproductive Health, 2019, 13:1179558119861936. 

[10] Rahimi Giti, Shams Saeideh, Aslani Mohammad Reza, et al. Effects of crocin supplementation on inflammatory markers, lipid profiles, insulin and cardioprotective indices in women with PCOS: A randomized, double-blind, placebo-controlled trial [J]. Phytotherapy research: PTR, 2022, 36(6): 2605-2615. 

[11] Cardoso Nathália Sigilló, Ribeiro Victor Barbosa, Dutra Sabrina Graziani Veloso, et al. Polycystic ovary syndrome associated with increased adiposity interferes with serum levels of TNF-alpha and IL-6 differently from leptin and adiponectin [J]. Archives of endocrinology and metabolism, 2020, 64(1):4-10. 

[12] Wang Y, Xiao H, Liu Y, et al. Effects of bu shen hua zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome [J]. Frontiers in Endocrinology, 2022, 13: 891297. 

[13] Wang Yang, Xiao Hui, Liu Yanxia, et al. Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome [J]. Frontiers in Endocrinology, 2022, 13:891297-891297. 

[14] Yousuf S D, Ganie M A, Urwat U, et al. Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women [J]. BMC Women's Health, 2023, 23(1): 68. 

[15] Elci Erkan, Kaya Cihan, Cim Numan, et al. Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries [J]. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology, 2017, 33(1):43-47. 

[16] Zeng Xin, et al. Mitochondrial Dysfunction in Polycystic Ovary Syndrome [J]. DNA and cell biology, 2020, 39(8):1401-1409. 

[17] Brenjian Samaneh, Moini Ashraf, Yamini Nazila, et al. Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers [J]. American journal of reproductive immunology (New York, N.Y.: 1989), 2020, 83(1):e13186. 

[18] Wang Can, Wen Yangxing, Mai Qingyun, et al. Impact of metabolic disorders on endometrial receptivity in patients with polycystic ovary syndrome [J]. Experimental and therapeutic medicine, 2022, 23(3):221-221. 

[19] Xiao Xinchun, Li Xiqin. Cases of the Clinical Treatment of Different Diseases with the Same Therapy by Guizhi Fuling Pill on Gynecological Diseases [J]. Journal of Shaanxi University of Chinese Medicine, 2018, 41(04):112-114+122. 

[20] Du Eryan, Zhang Xiujuan. Effect of Dual Treatment of Spleen and Kidney with Traditional Chinese Medicine to Dissipate Phlegm and Remove Blood Stasis Combined with Acupuncture on Coagulation Dysfunction and Hyperandrogenemia in Patients with Polycystic Ovary Syndrome [J]. Chinese Journal of Thrombosis and Hemostasis, 2017, 23(03):430-432. 

[21] Ding Yongfen, Cheng Ling, Lai Juan, et al. Invigorating-kidney Activating-blood Prescription in Treating 80 Patients of PCOS of Kidney-deficiency Blood-stasis Pattern [J]. Western Journal of Traditional Chinese Medicine, 2019, 32(04):97-99. 

[22] Chen Xufeng, Wei Yehong, Lv Ling, et al. Clinical Effects of Zuogui Soothing Liver Decoction on Polycystic Ovary Syndrome Infertility [J]. Chinese General Practice, 2017, 20(22):2796-2800.