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Frontiers in Medical Science Research, 2023, 5(10); doi: 10.25236/FMSR.2023.051020.

Mechanism of Xuanhuang Ointments for the Acute Soft Tissue Injury Based on Network Pharmacology


Rui Hua1, Miao Tan1, Yan Cheng2

Corresponding Author:
Yan Cheng

1Shaanxi University of Chinese Medicine, Xianyang, 712000, China

2Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, 710000, China


Screen the therapeutic target of XuanHuang Ointment on acute soft tissue injury by network pharmacology method, and to clarify its mechanism. The main chemical constituents and their targets of XuanHuang Ointment were obtained by using TCMSP database. The disease targets of acute soft tissue injury were searched by GeneCards .A compound-target-disease network was constructed using Cytoscape3.8.2 software. The targets were analyzed by GO analysis and KEGG enrichment analysis based on Metascape database. The core active components of XuanHuang Ointment were Quercetin, beta-sitosterol, Stigmasterol. The core target spots are: NCOA2, PTGS2, PTGS1, PGR and NR3C2 .Pathways in cancer, Lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications may play a potential role in XuanHuang Ointment in the treatment of acute soft tissue injury Signaling pathway. Conclusion XuanHuang Ointment has the characteristics of multiple components, multiple targets and overall regulation in the treatment of acute soft tissue injury.


XuanHuang Ointment; Acute soft tissue injury; Network pharmacology

Cite This Paper

Rui Hua, Miao Tan, Yan Cheng. Mechanism of Xuanhuang Ointments for the Acute Soft Tissue Injury Based on Network Pharmacology. Frontiers in Medical Science Research (2023) Vol. 5, Issue 10: 137-142. https://doi.org/10.25236/FMSR.2023.051020.


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