To study the clinical effect of immunoglobulin in the treatment of neonatal hemolytic disease. From January 2019 to January 2023, 45 children with hemolytic disease of newborns were selected and divided into two groups. The reference group was treated with blue light, while the experimental group was treated with immunoglobulin. The serum TBIL level, treatment situation, NBNA score, serum factor level and treatment effect were compared between the two groups. After treatment, the TBIL level of children in the experimental group decreased significantly and was lower than that in the reference group. Phototherapy time, jaundice regression time and hospitalization time of children in experimental group were shorter. After treatment, the NBNA scores of children in the experimental group were higher. After treatment, the serum factor level of the experimental group was lower. The therapeutic effect of children in the experimental group was better (p < 0.05). Immune immunoglobulin can effectively reduce the level of TBIL, accelerate the regression of jaundice and improve the therapeutic effect of neonatal hemolytic disease.

Zhang Wei, Wei Qian. Clinical analysis of immunoglobulin in the treatment of neonatal hemolytic disease. Frontiers in Medical Science Research (2023) Vol. 5, Issue 11: 29-33. https://doi.org/10.25236/FMSR.2023.051104.

[1] Zhang Li, Yang Xuelian, Hu Jinping. Effect of intravenous infusion of immunomagglobulin for neonatal hemolytic disease [J]. Chinese Science and Technology Journal Database (full-text edition) Medicine and Health care, 2023 (8): 0103-0106.

[2] Liu Liang, Zhang Manyun, Sun Huiqing. Clinical efficacy of immunogammagglobulin in the treatment of hemolytic disease in newborns [J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2023,33 (4): 82-84.

[3] Tan Zubing. Analysis of the effect of high-dose intravenous human immunoglobulin for the treatment of ABO hemolysis in neonates [J]. Pharmaceutical Frontier, 2023,13 (3): 76-78.

[4] Meng Lin. Laboratory test method and application effect analysis of hemolysis disease in neonates [J]. Chinese Science and Technology Journal Database (full-text edition) Medicine and Health care, 2023 (8): 0051-0054.

[5] Wu Meiling. Explore the use of evidence-based testing in neonatal hemolytic testing [J]. Chinese Science and Technology Journal Database (citation version) Medicine and Health care, 2023 (4): 0043-0045.

[6] Yan Guohong. Clinical effect analysis of sufentanil and remifentanil combined with propofol in hysteroscopic surgery [J]. Chinese Journal of Medical Sciences, 2019,13(04): 67-72.

[7] Zhang Hongmei. Investigation and analysis of a case of anti-c antibody during pregnancy [J]. Chinese Science and Technology Journal Database (full-text edition) Medicine and Health care, 2023 (6): 0019-0023.

[8] Huang Ling. Efficacy of intravenous infusion of immunomagglobulin for neonatal hemolytic disease [J]. Chinese Science and Technology Journal Database (Abstract edition) Medicine and Health, 2023 (1): 0041-0043.

[9] Cao Yanping. Effect of immune gamma globulin combined with blue light irradiation in neonatal hemolysis [J]. Big Doctor, 2023,8 (10): 45-47.

[10] Sun Ying, Pei Qianyun, Zhao Danmei. The value of 473 patients in children with suspected neonatal hemolysis [J]. Heilongjiang Medical Science, 2023,47 (17): 2123-2125.

[11] Li Yunqin, Guan Yin, Pei Yaochang. Analysis of the blood group test results in 124 ABO newborn patients [J]. Journal of Aerospace Medicine, 2023,34 (3): 276-278.