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Frontiers in Medical Science Research, 2023, 5(11); doi: 10.25236/FMSR.2023.051104.

Clinical analysis of immunoglobulin in the treatment of neonatal hemolytic disease

Author(s)

Zhang Wei, Wei Qian

Corresponding Author:
Wei Qian
Affiliation(s)

Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei, China

Abstract

To study the clinical effect of immunoglobulin in the treatment of neonatal hemolytic disease. From January 2019 to January 2023, 45 children with hemolytic disease of newborns were selected and divided into two groups. The reference group was treated with blue light, while the experimental group was treated with immunoglobulin. The serum TBIL level, treatment situation, NBNA score, serum factor level and treatment effect were compared between the two groups. After treatment, the TBIL level of children in the experimental group decreased significantly and was lower than that in the reference group. Phototherapy time, jaundice regression time and hospitalization time of children in experimental group were shorter. After treatment, the NBNA scores of children in the experimental group were higher. After treatment, the serum factor level of the experimental group was lower. The therapeutic effect of children in the experimental group was better (p < 0.05). Immune immunoglobulin can effectively reduce the level of TBIL, accelerate the regression of jaundice and improve the therapeutic effect of neonatal hemolytic disease.

Keywords

Immune gamma globulin; Newborns; Hemolytic disease

Cite This Paper

Zhang Wei, Wei Qian. Clinical analysis of immunoglobulin in the treatment of neonatal hemolytic disease. Frontiers in Medical Science Research (2023) Vol. 5, Issue 11: 29-33. https://doi.org/10.25236/FMSR.2023.051104.

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