Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2023, 5(11); doi: 10.25236/FMSR.2023.051110.

Research Progress on Multifactor Therapy for Lung Metastasis of Colorectal Cancer


Xia Chenyang1, Yao Xuequan2

Corresponding Author:
Yao Xuequan

1Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China

2Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210004, China


In recent years, the number of incidence and deaths of digestive tract tumors in the world has been increasing year by year, and colorectal cancer accounts for the largest proportion of digestive tract tumors, and its important cause of death is metastasis and recurrence after surgery. According to statistics, 20% of colorectal cancer patients have already developed distant metastasis at the time of first diagnosis. 50%-60% of colorectal cancer patients develop metastasis during the whole course of the disease, of which 10%-20% show lung metastasis. At present, the medical profession has proposed various treatment modes, such as drugs, surgery and intervention, for lung metastasis of different stages and degrees of colorectal cancer, which have effectively improved the prognosis of patients with lung metastasis of colorectal cancer. Therefore, this paper reviews the progress of colorectal cancer lung metastasis treatment.


Colorectal cancer; lung metastasis; surgical treatment; research progress

Cite This Paper

Xia Chenyang, Yao Xuequan. Research Progress on Multifactor Therapy for Lung Metastasis of Colorectal Cancer. Frontiers in Medical Science Research (2023) Vol. 5, Issue 11: 63-70. https://doi.org/10.25236/FMSR.2023.051110.


[1] Bray Freddie, Ferlay Jacques, Soerjomataram Isabelle, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA: a cancer journal for clinicians, 2018, 68(6):394-424. 

[2] Yuan Xing, Wei Qing, Ying Jie’er. Advances in the management of colorectal cancer with lung metastasis [J]. Journal of Colorectal & Anal Surgery, 2020, 26(2):133-136. 

[3] Riihimäki Matias, Hemminki Akseli, Sundquist Jan, et al. Patterns of metastasis in colon and rectal cancer [J]. Scientific reports, 2016, 6(1):29765. 

[4] Al-Ameri Mamdoh, Persson Michael, Bergman Per, et al. Long-term survival after surgery for pulmonary metastases from colorectal cancer: an observational cohort study [J]. Journal of thoracic disease, 2017, 9(11):4358-4365. 

[5] Zheng Rongshou, Zhang Siwei, Zeng Hongmei, et al. Cancer incidence and mortality in China, 2016 [J]. Journal of the National Cancer Center, 2022, 2(1):1-9. 

[6] Zhenghang Wang, Xicheng Wang, Jiajia Yuan, et al. Survival Benefit of Palliative Local Treatments and Efficacy of Different Pharmacotherapies in Colorectal Cancer with Lung Metastasis: Results From a Large Retrospective Study [J]. Clinical Colorectal Cancer, 2018, 17(2):e233-e255. 

[7] Paul Cavallaro, Liliana Bordeianou, Caitlin Stafford, et al. Impact of Single-organ Metastasis to the Liver or Lung and Genetic Mutation Status on Prognosis in Stage IV Colorectal Cancer [J]. Clinical Colorectal Cancer, 2020, 19(1):e8-e17. 

[8] Li Jian, Yuan Ying, Yang Fan, et al. Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition) [J]. Journal of hematology & oncology, 2019, 12(1):16. 

[9] Wang Zhenghang, Wang Xicheng, Yuan Jiajia, et al. Survival Benefit of Palliative Local Treatments and Efficacy of Different Pharmacotherapies in Colorectal Cancer with Lung Metastasis: Results From a Large Retrospective Study [J]. Clinical Colorectal Cancer, 2018, 17(2):e233-e255. 

[10] Hashiguchi Yojiro, Muro Kei, Saito Yutaka, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer [J]. International journal of clinical oncology, 2020, 25(1):1-42. 

[11] Chien-Hsin, Chen Mao-Chih, et al. Tumor location is an independent predictive factor for distant metastasis and metastatic sites of rectal adenocarcinoma in patients receiving total mesorectal excision [J]. Journal of Cancer, 2018, 9(6):950-958. 

[12] Maria Giulia Zampino, Patrick Maisonneuve, Paola Simona Ravenda, et al. Lung Metastases From Colorectal Cancer: Analysis of Prognostic Factors in a Single Institution Study [J]. The Annals of Thoracic Surgery, 2014, 98(4):1238-1245. 

[13] Park Hyung Soon, Jung Minkyu, Shin Sang Joon, et al. Benefit of Adjuvant Chemotherapy After Curative Resection of Lung Metastasis in Colorectal Cancer [J]. Annals of surgical oncology, 2016, 23(3):928-935. 

[14] Shen Tong, Liu Jinglin, Wang Chuyi, et al. Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer [J]. Signal Transduction and Targeted Therapy, 2021, 6(1):115-115. 

[15] Wang Dong, Wang Xiaohui, Song Yujia, et al. Exosomal miR-146a-5p and miR-155-5p promote CXCL12/CXCR7-induced metastasis of colorectal cancer by crosstalk with cancer-associated fibroblasts [J]. Cell Death & Disease, 2022, 13(4):380-380. 

[16] Lin Yun-Shan, Chiang Shu-Fen, Chen Chia-Yi, et al. Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation [J]. Cancer immunology immunotherapy, 2023, 72(7):2283-2297. 

[17] Benson Al B, Venook Alan P, AlHawary Mahmoud M, et al. Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology [J]. Journal of the National Comprehensive Cancer Network: JNCCN, 2022, 20(10):1139-1167. 

[18] Cervantes A, Adam R, Roselló S, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up [J]. Annals of oncology: official journal of the European Society for Medical Oncology, 2022, 34(1):10-32. 

[19] Cho Jong Ho, Kim Seok, Namgung Mi, et al. The prognostic importance of the number of metastases in pulmonary metastasectomy of colorectal cancer [J]. World journal of surgical oncology, 2015, 13(1):222. 

[20] Wang Weichen, Li Shaotang. Research progress in the comprehensive treatment of lung metastasis of colorectal cancer [J]. Journal of Colorectal & Anal Surgery, 2023, 29(3):216-220. 

[21] Menna Cecilia, Berardi Giammauro, Tierno Simone Maria, et al. Do repeated operations for recurrent colorectal lung metastases result in improved survival? [J]. The Annals of thoracic surgery, 2018, 106(2):421-427. 

[22] R.N. Younes, F. Abrao, J. Gross, et al. Pulmonary metastasectomy for colorectal cancer: Long-term survival and prognostic factors [J]. International Journal of Surgery, 2013, 11(3):244-248. 

[23] GómezAparicio Maria Antonia, Valero Jeannette, Caballero Begoña, et al. Extreme Hypofractionation with SBRT in Localized Prostate Cancer [J]. Current Oncology, 2021, 28(4): 2933-2949. 

[24] Kimura Tomoki, Fujiwara Toshiki, Kameoka Tsubasa, et al. Stereotactic body radiation therapy for metastatic lung metastases [J]. Japanese journal of radiology, 2022, 40(10):995-1005. 

[25] Jingu Keiichi, Matsuo Yukinori, Onishi Hiroshi, et al. Dose Escalation Improves Outcome in Stereotactic Body Radiotherapy for Pulmonary Oligometastases from Colorectal Cancer [J]. Anticancer research, 2017, 37(5):2709-2713. 

[26] Sinisa Stanic, Rebecca Paulus, Robert D. Timmerman, et al. No Clinically Significant Changes in Pulmonary Function Following Stereotactic Body Radiation Therapy for Early- Stage Peripheral Non-Small Cell Lung Cancer: An Analysis of RTOG 0236 [J]. International Journal of Radiation Oncology, Biology, Physics, 2014, 88(5):1092-1099. 

[27] Eric D. Brooks, Bing Sun, Lina Zhao, et al. Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients With Early-stage Non-Small Cell Lung Cancer [J]. International Journal of Radiation Oncology, Biology, Physics, 2016, 98(4):900-907. 

[28] Zhong Jim, Palkhi Ebrahim, Ng Helen, et al. Long-Term Outcomes in Percutaneous Radiofrequency Ablation for Histologically Proven Colorectal Lung Metastasis [J]. Cardiovascular and interventional radiology, 2020, 43(12):1-8. 

[29] Hasegawa Takaaki, Kuroda Hiroaki, Sakakura Noriaki, et al. Novel strategy to treat lung metastases: Hybrid therapy involving surgery and radiofrequency ablation [J]. Thoracic cancer, 2021, 12(14):2085-2092. 

[30] Qian Weiling. Effect of microRNA-6852 on the radiotherapy sensitivity of colon cancer cells SW480 through targeted regulation of the LEF1/AKR1C3 axis [J]. Journal of Xuzhou Medical University, 2021, 41(10):710-717. 

[31] Guadagnolo B Ashleigh, Liao Kai-Ping, Giordano Sharon H, et al. Increasing use of advanced radiation therapy technologies in the last 30 days of life among patients dying as a result of cancer in the United States [J]. Journal of oncology practice, 2014, 10(4):e269-e276.

[32] Ying Qiaoling, He Zelai, Guo Shunan, et al. Clinical evaluation of three-dimensional conformal intensity modulated radiotherapy for colorectal cancer oligometastases [J]. Chinese Journal of General Practice, 2019, 17(11):1802-1805. 

[33] Jing Hongyan, Tang Wenqian, Li Jinying, et al. Adverse reactions observation of intensity modulated radiation therapy combined with concurrent S-1 chemotherapy on colorectal cancer and Intervention [J]. Chinese Journal for Clinicians, 2016, 44(2):47-50. 

[34] El-Deiry Wafik S, Vijayvergia Namrata, Xiu Joanne, et al. Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites [J]. Cancer biology & therapy, 2015, 16(12):1726-1737. 

[35] Wen Guangming, Chen Yuanguang, Hu Ming, et al. Efficacy of one-stage resection of colorectal cancer and lung metastases by combined laparoscopic and thoracoscopic approach and prognostic factors [J]. Chinese Journal of General Surgery, 2015, 24(4):483-488. 

[36] Moore K H, McCaughan B C. Surgical resection for pulmonary metastases from colorectal cancer [J]. ANZ journal of surgery, 2001, 71(3):143-146.