In order to evaluate the clinical efficacy and safety of Banxia Xiexin decoction in the treatment of chronic cholecystitis, and to provide evidence for the clinical application of Banxia Xiexin decoction. We searched CNKI, VIP, WFPD and CBM databases for clinical randomized controlled trials (RCTS) on Banxia Xiexin decoction in the treatment of chronic cholecystitis. The retrieved literature was screened according to strict inclusion and exclusion criteria. The data were analyzed by using RevMan 5.4.1 software. Resultly, a total of 14 RCTs involving 1127 patients were included, with 566 in the treatment group and 561 in the control group. All the studies reported the total effective rate, 6 studies reported the cure rate, and 3 studies reported the adverse reactions after treatment. Four articles reported the recurrence rate. Three articles reported improvement in abdominal distension and four articles reported improvement in abdominal pain. The results of Meta-analysis showed that the cure rate of Banxia Xiexin decoction in the treatment of chronic cholecystitis was better than the control group (RR=1.66, 95%CI[1.20, 2.30], P=0.002), and the total effective rate was higher than that of the control group (RR=1.23, 95%CI[1.17, 1.29], P<0.00001). Compared with the control group, it had an advantage in preventing disease recurrence (RR=0. 25, 95%CI(0.15, 0.40), P<0.00001). It also improved the symptoms such as abdominal distension (MD=-0.56, 95%CI[-0.87, -0.25], P=0.0004) and abdominal pain (MD=-0.70, 95%CI[-1.21, -0.19], P=0.007). In conclusion, Banxia Xiexin decoction has a good clinical effect on chronic cholecystitis. However, due to the low quality of the included studies, more high-quality randomized double-blind controlled trials are needed to further verify the conclusion, so as to provide more reliable evidence for the treatment of chronic cholecystitis with Banxia Xiexin decoction.

Lu Cheng, Yuanshan Tang, Ruyu Teng, Xiaojing Zhu. Meta-analysis of Banxia Xiexin Decoction in Treatment of Chronic Cholecystitis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 11: 71-78. https://doi.org/10.25236/FMSR.2023.051111.

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