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Frontiers in Medical Science Research, 2023, 5(11); doi: 10.25236/FMSR.2023.051117.

Research Progress on the Association between Depression and Coronary Heart Disease and Diabetes


Yong Tan1, Bairong Wang1, Danyang Hao1, Xuebin Chen2

Corresponding Author:
Xuebin Chen

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2Department of Cardiology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China


As one of the important mental diseases, depression is closely related to coronary heart disease and diabetes. Depression belongs to the category of "depression" and "insomnia" in traditional Chinese medicine, among which coronary heart disease and diabetes are manifested in traditional Chinese medicine as depression caused by heartache, depression caused by thirst, disease depression, etc. Related studies have shown that MAPK signaling pathway, NF-κB signaling pathway, inflammatory response, HPA axis dysfunction, neurotrophic reduction, oxidative stress, insulin resistance, intestinal flora dysbiosis, behavioral abnormalities play important roles in the comorbidity pathological mechanism. This article summarizes relevant literature in recent years, exploring the etiology of traditional Chinese medicine and the pathogenesis of Western medicine, in order to provide reference for its clinical treatment.


Depression; coronary heart disease; diabetes; traditional Chinese and Western medicine; research progress

Cite This Paper

Yong Tan, Bairong Wang, Danyang Hao, Xuebin Chen. Research Progress on the Association between Depression and Coronary Heart Disease and Diabetes. Frontiers in Medical Science Research (2023) Vol. 5, Issue 11: 115-123. https://doi.org/10.25236/FMSR.2023.051117.


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