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Frontiers in Medical Science Research, 2023, 5(12); doi: 10.25236/FMSR.2023.051213.

Combination of Chinese and Western medicine in the treatment of a patient with syphilitic myelitis secondary to a brain lesion


Zhang Xuanyue1, Ba Li1, Liu Hanjiao2

Corresponding Author:
Liu Hanjiao

1Shenzhen Bao'an Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, Guangzhou, China

2Shenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen, 518133, Guangzhou, China


Syphilitic myelitis is a rare manifestation of neurosyphilis that has received little attention in the literature. This paper discusses the case of a 40-year-old female patient with a history of incompletely treated syphilis who presented with several weeks of progressive numbness and weakness in both legs in January following a high-risk sexual behaviour. The clinical examination revealed that this patient had muscle strength grade 3 in the left lower limb and grade 4 in the right lower limb, normal muscle tone in all four limbs, decreased sensation in the left lower limb compared to the right lower limb, and bilateral Hoffmann(+) bilateral Babinski(+). A cranial MRI scan revealed a few patchy and sheet-like abnormal signal shadows in the semi-ovoid centre. A spinal cord MRI scan revealed an aberrant signal in the spinal cord (cervical 2-thoracic 12 level), suggesting a high possibility of spondylitis. The patient was diagnosed with syphilitic myelitis, ruling out other infectious or immunologic aetiologies. The patient was given intravenous penicillin and intravenous methylprednisolone at 1 g daily for 3 days. The medication was gradually reduced and then withdrawn. During outpatient follow-up, the patient improved and had no relapse of symptoms. This paper demonstrates the exceptional efficacy of TCM methods for the treatment of syphilitic myelitis.


Syphilitic myelitis, combined Chinese and Western medicine therapies, nursing

Cite This Paper

Zhang Xuanyue, Ba Li, Liu Hanjiao. Combination of Chinese and Western medicine in the treatment of a patient with syphilitic myelitis secondary to a brain lesion. Frontiers in Medical Science Research (2023) Vol. 5, Issue 12: 97-102. https://doi.org/10.25236/FMSR.2023.051213.


[1] Chow, F., Neurosyphilis. continuum (Minneap Minn), 2021. 27(4): p. 1018-1039.

[2] Skalnaya, A., et al., Neurosyphilis in the modern era: literature review and case series. j Clin Neurosci, 2019. 69: p. 67-73.

[3] Wan Congchong, Special neurosyphilis: clinical features and diagnostic analysis of syphilitic myelopathy, 2018, Suzhou University.

[4] Ramrakhiani, N., P.K. Sukhani and R. Dubey, Neurosyphilis - A Forgotten Disease: Case Reports with Ten Years Follow-Up and Review of Literature. neurol India, 2020. 68(4): p. 889-893.

[5] Lu H et al, Two cases of syphilitic myelitis presenting as long segmental myelopathy and literature review. Chinese Journal of Neurology, 2016. 49(12): pp. 967-969.

[6] Gong Ouqiang et al. Characterization of clinical cases of surgical treatment of syphilitic myelitis. Journal of Changchun University of Traditional Chinese Medicine, 2021. 37(04): pp. 848-850.

[7] Elmouden, H., N. Louhab and N. Kissani, Medullary involvement in neurosyphilis: a report of 12 cases and a review of the literature. spinal Cord Ser Cases,. 2019. 5: p. 38.

[8] Li R et al, Three cases of syphilitic myelitis and literature review. Zhejiang Medicine, 2019. 41(11): pp. 1221-1224.

[9] A, W.K., Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. 61 Suppl 8(suppl 8).

[10] Drago, F., G. Ciccarese and A. Parodi, Cerebrospinal fluid tests for neurosyphilis diagnosis. Sex Transm Infect, 2020. 96(5): p. 387.

[11] M. Hannuksela, E.O. Karaharju, Syphilis of the spine, Br. J. Vener.Dis. 48 (1972) 397-399. 

[12] J.P. Nielsen, Follow-up of syphilitics; late manifestations in 467 male patients with early syphilis followed for 29-36 years, Acta Derm. Venereol. 30 (1950) 507-512. 

[13] Bhai S, Lyons JL. Neurosyphilis update: Atypical is the newtypical. Curr Infect Dis Rep. 2015;17(5):481. doi:10.1007/s11908-015-0481-x

[14] Yuan JL, Wang WX, Hu WL. Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinalmagnetic resonance imaging. World J Clin Cases. 2019;7(11):1282-1290. doi:10.12998/wjcc.v7.i11.1282

[15] Chilver-Stainer L, Fischer U, Hauf M, Fux CA, Sturzenegger M. Syphilitic myelitis: Rare, nonspecific, but treatable. Neurology. 2009;72(7):673- 675. doi:10.1212/01.wnl.0000342460.07764.5c

[16] Yang, H., Zheng, M. F. & Qu, D. B. Diagnosis and treatment of rare syphilitic myelitis with pathologic confirmation: report of two cases and review of the literature. Journal of Molecular Imaging, 2020. 43(03): pp. 444-448.

[17] Meng Tenteng, Clinical Study of Acupuncture at Baihui and Si Shencong Points on Cognitive Function in Stroke Patients, 2019, Shandong University of Traditional Chinese Medicine.

[18] Liu Y, Electroacupuncture of the four Shencong points with moxibustion for the treatment of post-stroke cognitive impairment technique finishing study. World Digest of Recent Medical Information, 2019. 19(A4): pp. 256-257.

[19] Skalnaya, A., et al., Neurosyphilis in the modern era: literature review and case series. j Clin Neurosci, 2019. 69: p. 67-73.