Welcome to Francis Academic Press

Frontiers in Medical Science Research, 2023, 5(12); doi: 10.25236/FMSR.2023.051217.

Overview of Clinical Applications of Guizhi Fuling Pills


Yao Luyao

Corresponding Author:
Yao Luyao

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China


Guizhi Fuling Pill is a classic formula from Zhang Zhongjing's "The Essentials of the Golden Chamber", which has the effect of activating blood circulation and removing blood stasis, etc. In recent years, Guizhi Fuling Pill has been widely used in the domestic clinic, which can not only treat gynecological diseases such as uterine fibroids, ovarian cysts, polycystic ovary syndrome, endometriosis, pelvic inflammatory disease, and adenomyosis, but also play a positive therapeutic role in diseases such as prostatic hyperplasia, coronary artery disease, chronic obstructive pulmonary disease, and hyperlipoproteinemia. Lipoproteinaemia and other diseases have also played a positive therapeutic role. This paper summarises and analyses the clinical application of Guizhi Fuling Pills in recent years to provide a basis for further broadening the scope of clinical use.


Guizhi Fuling Pill; Clinical application; Research progress; Gynecology

Cite This Paper

Yao Luyao. Overview of Clinical Applications of Guizhi Fuling Pills. Frontiers in Medical Science Research (2023) Vol. 5, Issue 12: 120-125. https://doi.org/10.25236/FMSR.2023.051217.


[1] Niu Yi. Clinical study on the efficacy of the addition and subtraction of Guizhi Poria pills in the treatment of uterine fibroids[D]. Chengdu: Chengdu University of Traditional Chinese Medicine. 2020

[2] Yang Jing. Clinical effect of mifepristone combined with Guizhi Poria pill in the treatment of uterine fibroids[J]. Marriage and Health, 2023, 29(12): 19-21.

[3] Guo Ruihua, Feng Yun. Clinical effect of LNG-IUS combined with Guizhi Poria pill in the treatment of uterine fibroids and its effect on hormone levels[J]. Clinical Medical Research and Practice, 2021,6(15): 150-152.

[4] Wang Tingting. Clinical effect of Guizhi Poria pills combined with mifepristone in the treatment of uterine fibroids with qi stagnation and blood stasis[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2022, 41(10): 62-64.

[5] Wang Jiahui, Ma Zengxiang. Research progress on the direct economic burden of polycystic ovary syndrome and its complications[J]. Journal of Health Economics, 2022,39(3): 24-27.

[6] Li Jiannan, Yu Fengying, Shen Huanhuan, et al. Efficacy of Guizhi Poria Cocos Pill Combined with Western Medicine in the Treatment of Polycystic Ovary Syndrome and Its Regulatory Effect on PI3K/AKT/mTOR Pathway[J]. Journal of Molecular Diagnosis and Therapeutics, 2023,15(2): 197-200+204.

[7] Yu Jingwei, Zhong Xiaoying, Zeng Lei, et al. Effect and mechanism of Guizhi Poria pill on phlegm-wet polycystic ovary syndrome model rats[J]. China Pharmacy, 2021, 32(1): 39-45.

[8] Guidelines for the diagnosis and treatment of endometriosis with integrated traditional Chinese and Western medicine[J]. Clinical Medicine Research and Practice, 2019, 4(31): 201. https://kns.cnki.net/kcms2/article/abstract?v=ohXIcpZjJKweyyJL8b2evr2qTX4yr_BzPQJxxpS0BNUTft35n_TYvP2K3Y42y0v5fSUt_5lWC0lflQZk6H3UPM4qTLXsicYVzQuwIT8k6EYhig_x_yev9PvBgw  WnrP56h_JqvcjuguhCTOBmdqWCVw==&uniplatform=NZKPT&language=CHS

[9] Lin Yongqing, Liu Yuejun, Zhang Shaofen, et al. Interpretation of the guidelines for endometriosis of the 2022 European Society of Human Reproduction and Embryology[J]. Advances in Modern Obstetrics and Gynecolog, 2023, 32(6): 452-454+457.

[10] Wu Yuhua, Luo Xiaoqin, Tong Zhiqin. Clinical efficacy and safety of Guizhi Poria pill combined with dydrogesterone in the treatment of endometriosis[J]. Clinical Rational Use of Medicine, 2023,16(6): 131-133.

[11] Yao Li, Lv Yanchun, Cai Wanming, et al. Clinical study on the treatment of endometriosis with Guizhi Poria pills combined with dienogest[J]. Modern Medicine and Clinical Medicine, 2022,37(11): 2588-2592.

[12] Liu Xiaojuan, Fan Aiping, Xue Fengxia. Interpretation of the 2015 Centers for Disease Control and Prevention on the diagnosis and treatment of pelvic inflammatory disease[J]. International Journal of Obstetrics and Gynecology, 2015,42(6): 674-675+684.

[13] Wang Jiaxian, Liu Beimei, Zheng Qingdan. Value analysis of the treatment of chronic pelvic inflammatory disease with Guizhi Poria pills[J]. Harbin Medicine, 2021, 41(4): 128-130.

[14] Zhang Haiyan. Research Progress on Clinical Application of Guizhi Poria Pills[J]. Gansu Medicine, 2022, 41(2): 105-106+112.

[15] Chao Hongtu, Luo Yanlin. What to do if an ovarian cyst is found[J]. Jiangsu Health Care, 2022 (10): 24.

[16] Xiong Deling, Liu Changyan, Li Ying, et al. Effect of Gynecological Qianjin Capsule Combined with Guizhi Poria Pill on Serum NO, TNF-α and Sex Hormone Levels in Elderly Patients with Ovarian Cysts[J]. Advances in Modern Biomedicine, 2017, 17(30): 5925-5928.

[17] You Junwen, Jia Menghui. Clinical efficacy of Guizhi Poria Pill combined with Jiawei Xiaoyao Pill in patients with simple ovarian cyst[J]. Chinese Journal of Proprietary Medicine, 2019, 41(11): 2651-2655.

[18] Sun Jiaying, Zhang Yayun, Chen Yuanna. Effect of Guizhi Poria Cocos Pill in the Treatment of Adenomyosis and Its Effect on JAK2 and STAT3 Expression[J]. China Maternal and Child Health, 2021,36(3): 658-661.

[19] Jing Manfang, Feng Xiaomin. Efficacy of Guizhi Poria Pill in the Treatment of Prostatic Hyperplasia in 42 Cases[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2016, 35(8): 49.

[20] Wang Zulong. Treatment of chronic epididymitis with flavor of Guizhi Poria pills in 68 cases[J]. Henan Journal of Traditional Chinese Medicine, 2007 (5): 17.

[21] Ren Enhua, Fu Senhao. Advances in traditional Chinese medicine (TCM) treatment of chronic prostatitis[C]. Andrology Committee of Chinese Association of Integrative Medicine, 2017,423-424.

[22] Jia Rui. Guizhi Poria Pill plus flavor treatment of semen non-liquefaction in 54 cases[C]//Proceedings of the 14th Andrology Academic Conference of the Chinese Association of Traditional Chinese Medicine. China Association of Traditional Chinese Medicine, 2014, 340-341.

[23] Zhang Yaping, Wang Hongmei, Xie Xue, et al. Mechanism of anti-benign prostatic hyperplasia of Guizhi Poria capsules[J]. Drug Evaluation Research, 2023,46(7): 1472-1479.

[24] Zhou Wenrui. Clinical study on the addition and subtraction of Guizhi Poria pills in the treatment of stasis obstructive chest paralysis[J]. Shanghai Medicine, 2017, 38(20): 17-19.

[25] Yu T, Shi Qing, Zhong Yongfu, et al. Therapeutic effect of traditional Chinese medicine Guizhi Poria pills on cognitive function of cerebrovascular disease[J]. Chinese Medical Sciences, 2007,11(13): 64-67.

[26] Sun Yuexia. Addition and subtraction of Guizhi Poria pills in the treatment of hyperlipoproteinemia[J]. Western Medicine, 2007 (4): 662-663.

[27] Liu Xiaoshuai, Wang Guo, Wang Lin, et al(). Experimental study on the resistance of Guizhi Poria pills to chronic heart failure in rats[J]. Journal of Southwest University for Nationalities (Natural Science Edition), 2017,43(4): 378-385.

[28] Chen Yongqing, Hong Xiaobing, Zhang Junli, et al. Effect of Jiawei Guizhi Poria Cocos Pill on Inflammatory Markers and Pulmonary Artery Pressure Related to Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J]. Zhejiang Journal of Traditional Chinese Medicine, 2023, 58(2): 103-104.

[29] Ji Junrong, Huang Yan, Zhao Liping, et al. Effect of Xiao Chai Hu Tang and Gui Zhi Poria Pills on Pulmonary Function and Recurrence Rate of Bronchial Asthma[J]. Chinese Journal of Medical Innovation, 2021,18(33): 87-91.

[30] Chen Ting, Shi Le, Jin Dianchun. Jin Dianchun's experience in using Guizhi Poria pills in the treatment of pulmonary nodules[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2023 42(5): 74-75.