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Frontiers in Medical Science Research, 2024, 6(1); doi: 10.25236/FMSR.2024.060109.

Research Progress on Transient Receptor Potential Channels and Myocardial Fibrosis


Rong Fang, Yuanwang Yu

Corresponding Author:
Yuanwang Yu

School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China


Cardiovascular disease seriously endangers human health, and its morbidity and mortality increase year by year, and the incidence population is gradually younger. Myocardial fibrosis is a common pathological outcome of many heart diseases, and it is of great clinical significance to prevent and reverse cardiac fibrosis. Under the influence of various pathogenic factors, the heart eventually leads to the formation of myocardial fibrosis, which in turn leads to heart failure. However, the specific mechanism of myocardial fibrosis formation is unknown. The transient receptor potential channel is closely related to the formation of myocardial fibrosis, and can be targeted to intervene in this channel to play an antifibrotic role. This review elaborates the role of transient receptor potential channels in the formation of myocardial fibrosis, which provides new ideas for clinical treatment and basic research.


Fibroblast; Myofibroblasts; TGF-β; Ca2+; TRP channel

Cite This Paper

Rong Fang, Yuanwang Yu. Research Progress on Transient Receptor Potential Channels and Myocardial Fibrosis. Frontiers in Medical Science Research (2024), Vol. 6, Issue 1: 49-54. https://doi.org/10.25236/FMSR.2024.060109.


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