International Journal of Frontiers in Medicine, 2024, 6(1); doi: 10.25236/IJFM.2024.060106.
Rongbing Fu1, Wei Liang1, Jingkai Zhou1, Yufeng Zhao1,2, Libei Huang1, Hongshen Zhang1,2,3
1School of Pharmacy, Youjiang Medical University For Nationalities, Baise, 533000, China
2Key Laboratory of Right River Basin Characteristic Ethnic Medicine Research in Guangxi, Baise, 533000, China
3Guangxi Database Construction and Application Engineering Research Center for Intracorporal Pharmacochemistry of TCM, Baise 533000, China
This study investigated the effectiveness of Jiawei Sanzi Yangqin Decoction (JSYD) in asthma treatment, utilizing network pharmacology and molecular docking methods. The key components of JSYD and their targets were pinpointed using the TCMSP database, while specific asthma-related targets were collated from the GeneGards and Disgenet databases. We constructed interaction networks between JSYD components and biological targets using Cytoscape 3.9.1 and the STRING database. This was followed by gene ontology and pathway analysis via Metascape. Selected targets and ingredients underwent molecular docking, were analyzed using AutoDockTools Vina, and visualized with Pymol. Our findings emphasize that the constituents of JSYD, especially kaempferol, interact with various molecules, such as IL-6, and affect key pathways, including Th17 cell differentiation. This research highlights the comprehensive potential of JSYD in asthma management and paves the way for more in-depth studies.
Asthma, Jiawei Sanzi Yangqin Decoction, Network Pharmacology, Molecular Docking
Rongbing Fu, Wei Liang, Jingkai Zhou, Yufeng Zhao, Libei Huang, Hongshen Zhang. Mechanism of Jiawei Sanzi Yangqin Decoction in the Treatment of Asthma Based on Network Pharmacology and Molecular Docking. International Journal of Frontiers in Medicine (2024), Vol. 6, Issue 1: 42-51. https://doi.org/10.25236/IJFM.2024.060106.
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