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Frontiers in Medical Science Research, 2024, 6(2); doi: 10.25236/FMSR.2024.060201.

Streptococcus Pneumoniae Teichoic Acids


Miao Yao1,2, Yumeng Hu1,2, Jiali Chen1,2, Kaifeng Wu1,2

Corresponding Author:
Kaifeng Wu

1Department of Laboratory Medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, 563000, China

2Scientific Research Center, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, 563000, China


Teichoic acids (TAs) are one of the key virulence factors of S. pneumoniae, as well as one of the key components of the bacterial cell wall. The complexity of TAs structure and biosynthesis stems from its diverse functions and roles, including their involvement in the regulation of bacterial virulence and bacterial division, it also plays a crucial role in bacterial transformation. In this paper, the basic structure and biosynthesis of teichoic acid in S. pneumoniae were described. Meanwhile, the functions of TAs in the pathogenic mechanism of S. pneumoniae, the regulatory factors of biosynthesis, and the effects in vaccines are summarized. Finally, we also provide a perspective for future research. This review may provide a foundation for further studies to provide the pathogenic mechanism of TAs in S. pneumoniae and a theoretical basis for the design of vaccines.


Streptococcus pneumoniae; Teichoic acids; biosynthetic; vaccine

Cite This Paper

Miao Yao, Yumeng Hu, Jiali Chen, Kaifeng Wu. Streptococcus Pneumoniae Teichoic Acids. Frontiers in Medical Science Research (2024), Vol. 6, Issue 2: 1-9. https://doi.org/10.25236/FMSR.2024.060201.


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