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Frontiers in Medical Science Research, 2024, 6(2); doi: 10.25236/FMSR.2024.060205.

Correlation Analysis between lncRNA HOXA-AS2 of Circulating Tumor Cells and Radiotherapy Sensitivity in Colon Cancer


Cheng Duanhui, Huang Weizheng, Lai Yingsen, Lei Guojian

Corresponding Author:
Cheng Duanhui

The Sixth People's Hospital of Nanning, Nanning, 530003, China


The aim of this study is to analyze the association between lncRNA HOXA-AS2 in circulating tumor cells (CTC) and the radiotherapy sensitivity of colon cancer. The researchers detected the expression of HOXA-AS2 in cancer tissues and peripheral blood CTC of colon cancer patients with radiotherapy sensitivity and radiotherapy tolerance by RT-PCR method. Subsequently, radiotherapy-tolerant colon cancer cells were cultured in vitro, and HOXA-AS2 was silenced by cell transfection, followed by radiation therapy. The apoptosis of cells after radiotherapy was observed by MTT assay. The results showed that compared with radiotherapy-tolerant patients, HOXA-AS2 was significantly down-expressed in cancer tissues and CTC of radiotherapy-sensitive patients, and the difference was statistically significant (P<0.05). The radiotherapy sensitivity of colon cancer cells with silenced HOXA-AS2 was significantly improved, and the difference was also statistically significant (P<0.05). This indicates that the high expression of HOXA-AS2 in CTC is negatively associated with the radiotherapy sensitivity of colon cancer cells.


Circulating tumor cells, lncRNA HOXA-AS2, colon cancer, radiotherapy sensitivity

Cite This Paper

Cheng Duanhui, Huang Weizheng, Lai Yingsen, Lei Guojian. Correlation Analysis between lncRNA HOXA-AS2 of Circulating Tumor Cells and Radiotherapy Sensitivity in Colon Cancer. Frontiers in Medical Science Research (2024), Vol. 6, Issue 2: 28-31. https://doi.org/10.25236/FMSR.2024.060205.


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