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Academic Journal of Medicine & Health Sciences, 2024, 5(2); doi: 10.25236/AJMHS.2024.050204.

To Explore the Correlation between the Severity of Chronic Kidney Disease and the Hemodynamics of Small Cerebral Vessels under Transcranial Color Doppler


Huiting Fang1, Shuang Wang1, Shichao Liu1, Yujie Li1, Yin Zhang2, Shumei Shan1, Kemin Xi1, Yue Qiao1, Yue Li1

Corresponding Author:
Shumei Shan

1Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, 157000, China

2Heilongjiang Provincial Hospital, Harbin, 150000, China


The purpose of this study is to investigate the correlation and its clinical value between the severity of chronic kidney disease and cerebral arterial blood flow dynamics by transcranial color-coded duplex sonography (TCCD). We collected patients with cerebral small vessel disease with chronic kidney disease (CKD) who visited Hongqi Hospital affiliated with Mudanjiang Medical University, gathered between October 2020 and December 2021. The results were analyzed and then divided into 3 groups according to different stages of CKD: 73 patients in CKD stage Ⅰ-Ⅲ, CKD-IV, and CKD-V.Those with stable serum creatinine and small cerebral vascular lesions without stenosis or occlusion of intracranial large vessels were examined by TCCD. The spectrum data of intracranial great vessels of the three groups were measured and the vascular resistance index (RI) and pulsatility index (PI) were calculated. The obtained data were analyzed statistically. Finally, it is concluded that: ①There was no significant difference in general data (gender and age) among the 3 groups (p>0.05); ②There was no statistically significant difference between the bilateral anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) RI and PI values in the three groups (p>0.05).③There were no significant differences in ACA-PI and PCA-PI values among the three groups (p > 0.05). Each of the three groups' MCA-PI levels corresponded to a different stage of CKD in the patients. Patients with stage V CKD had PI levels that were noticeably greater than those of patients with stages I–III and IV. ④At various stages of CKD, there was a linear relationship between the MCA-PI value and serum creatinine level; also, the MCA-PI value increased linearly as the serum creatinine level increased. To sum up, TCCD has certain clinical application value for stroke risk assessment in CKD patients with small cerebral vessel diseases. It can capture the small cerebral blood flow changes in CKD patients at an early stage, non-invasive assessment of potential stroke probability in CKD patients, and help clinical physicians intervene early to lower the incidence and death of cerebrovascular disorders in patients with chronic kidney disease.


Transcranial Color-Coded Duplex Sonography; Chronic Kidney Disease; Small Cerebral Vascular Disease

Cite This Paper

Huiting Fang, Shuang Wang, Shichao Liu, Yujie Li, Yin Zhang, Shumei Shan, Kemin Xi, Yue Qiao, Yue Li. To Explore the Correlation between the Severity of Chronic Kidney Disease and the Hemodynamics of Small Cerebral Vessels under Transcranial Color Doppler. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 2: 22-29. https://doi.org/10.25236/AJMHS.2024.050204.


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