To study the risk factors of criticalization and death in hospitalized patients with COVID-19 infection. 320 patients with COVID-19 infection admitted to a tertiary hospital from January to October 2023 were collected, and unifactorial and multifactorial analyses were performed in terms of clinical features, laboratory test results, imaging examinations and treatment measures to find out the risk factors related to the critical deterioration and death of patients hospitalized with new crown among them. The results of multifactorial analysis showed that prolonged hospitalization days, decreased absolute serum lymphocyte values, decreased CD4+ T lymphocytes, increased IL6 counts, and chest CT inflammatory index classification grade IV were risk factors for the evolution of critical illness in patients with COVID-19 infection, whereas comorbid diabetes mellitus, decreased absolute serum lymphocyte values, decreased CD4+ T lymphocytes, and increased IL6 counts were risk factors for death in patients with COVID-19 infection critical illness. The combined test of blood IL-6 and lymphocyte levels and imaging chest CT inflammatory index grading can assess the inflammatory response, immune function, and lung lesion status in patients with COVID-19 infection pneumonia, thus making a prognosis of disease severity and prognosis. Patients with diabetes mellitus, progressive decrease in lymphocyte count, increase in IL-6 level, and grade IV of chest CT inflammation index should be alerted, to achieve early detection, early diagnosis, early intervention, early adjustment of the treatment plan, avoid progressive disease progression, and reduce the rate of criticalization and mortality.

Quan Zeng, Xin Xiaojuan. Analysis of Risk Factors for Criticalization and Death in Hospitalized Patients with COVID-19 Infection in the Post Epidemic Era. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 2: 30-40. https://doi.org/10.25236/AJMHS.2024.050205.

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