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Academic Journal of Medicine & Health Sciences, 2024, 5(2); doi: 10.25236/AJMHS.2024.050207.

Research progress of ellagic acid in systemic and oral diseases


Alida Yumubek1,2, Tursungul Kahar1,2, Gulinuer Awuti1,2

Corresponding Author:
Gulinuer Awuti

1Dept. of Periodontology, The First Affiliated Hospital of Xinjiang Medical University/Affiliated College of Stomatology, Urumqi, 830011, China

2Stomatology Disease Institute of Xinjiang Uy‐ghur Autonomous Region, Urumqi, 830011, China


Ellagic acid (EA) is a kind of natural polyphenol dilactone derived from pomegranate, grape, strawberry and other fruits and nuts, which has a high content in pomegranate peel. A large number of research results show that ellagic acid has anti-tumor, antiviral, antioxidant, anti-inflammatory, anti-allergic, anti-fibrosis and other pharmacological activities. In the past ten years, more and more attention has been paid to the study of the physiological effect and mechanism of ellagic acid. Therefore, this paper reviews the relevant literature at home and abroad, and summarizes the role of ellagic acid in systemic and oral diseases in recent years.


ellagic acid, Polyphenols, Biological activity

Cite This Paper

Alida Yumubek, Tursungul Kahar, Gulinuer Awuti. Research progress of ellagic acid in systemic and oral diseases. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 2: 46-49. https://doi.org/10.25236/AJMHS.2024.050207.


[1] Wu Jianhua, Wu Zhikui, Pei Jianguo, Liu Jing, Sun Yanchao, WU Guofang, Peng Shuimei, Fu Xiaomei. Research progress of polyphenols [J]. Chinese Journal of Modern Chinese Materia Medica, 2015, 17(06):630-636. 

[2] Ding Nan, GAO Xiaoli. Determination of ellagic acid in pomegranate peel extract by HPLC [J]. Journal of Xinjiang Medical University,2012,35(06):770-772.

[3] Gao XP, Zhang Lihua. Research progress of ellagic acid extraction from pomegranate peel [J]. Modern Agricultural Science and Technology,2020(14):218-220.

[4] Carmen Vanessa Ortiz-Ruiz et al. Action of ellagic acid on the melanin biosynthesis pathway[J]. Journal of Dermatological Science, 2016, 82(2): 115-122. 

[5] Baradaran Rahimi Vafa et al. Antiinflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies.[J]. Phytotherapy research : PTR, 2020, 34(4) : 685-720.

[6] Lv G. Study on the inhibitory effect of ellagic acid on lipopolysaccharide-induced inflammation and its mechanism [D]. Jilin University,2016.

[7] Dell'agli M, Galli GV. Ellagitannins of the fruit rind of pomegranate antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria. Malar J. 2010 Jul 19; 8 ruler.

[8] Espin Juan Carlos et al. Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far.[J]. Evidence-based complementary and alternative medicine : eCAM, 2013, 2013 : 270418.

[9] Les F, Arbones-Mainar JM, Valero MS, Lopez V. Pomegranate polyphenols and urolithin A inhibit alpha-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. J Ethnopharmacol. 2018 Jun 28; 220:67-74. 

[10] Yan L, ZHOU X Y. Study on the bacteriostatic effect of ellagic acid on Streptococcus mutans in vitro and its mechanism [J]. Chinese Pharmacy, 2019,31(05):607-611. 

[11] Min Zhao et al. Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice[J]. Cancer Letters, 2013, 337(2) : 210-217.

[12] Edderkaoui Mouad et al. Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells[J]. World Journal of Gastroenterology : WJG, 2008, 14(23) : 3672-3680.

[13] Radha Munagala et al. MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention[J]. Cancer Letters, 2013, 339(2): 175-184.

[14] Zhong C. Molecular mechanism of ellagic acid inhibiting hepatocarcinoma and its synergistic effect with two chemotherapeutic agents [D]. Northeast Forestry University,2019.

[15] Gonzalez-Sarrias A et al. Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial. [J]. Food & function, 2018, 9(5): 2617-2622.

[16] Baradaran Rahimi Vafa et al. Antiinflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies.[J]. Phytotherapy research : PTR, 2020, 34(4) : 685-720.

[17] Hiroshi Ohshima et al. Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion[J]. Free Radical Biology and Medicine, 1998, 25(9): 1057-1065.

[18] Amira Ragab EL Barky and Tarek Mostafa Mohamed and Ehab Mostafa Mohamed Ali. Detoxifying and antioxidant effect of ellagic acid nano particles in rats intoxicated with sodium nitrites[J]. Applied Biological Chemistry, 2020, 63(1) : 322-332.

[19] Ziemska J, Szynal T, Maza productive ska M, Solecka J. Natural medicinal resources and their therapeutic applications. Rocz Panstw Zakl Hig. 2019; 70 (4) : 407-413.

[20] Fatima Noor et al. Ellagic acid in Emblica officinalis exerts anti-diabetic activity through the action on beta cells of mice pancreas.[J]. European journal of nutrition, 2017, 56(2) : 591-601.

[21] Manna K et al. Amelioration of diabetic nephropathy using pomegranate peel extract-stabilized gold nanoparticles: assessment of NF-κB and Nrf2 signaling system[J]. International Journal of Nanomedicine, 2019, Volume 14:1753-1777.

[22] N. Babay and F. Alshehri and R. Al Rowis. Majors highlights of the new 2017 classification of periodontal and peri-implant diseases and conditions[J]. The Saudi Dental Journal, 2019, 31(3) : 303-305

[23] Xue Mingyue, Luo Xingye, Zhan Zhihua, Chen Quanbin. Experimental study on anti-allergenic effect of ellagic acid in sweet tea [J]. Food Research and Development, 2012, 33(11):208-211.

[24] Zhong Lili, Yu Ying, YI Yajing, Ni Xueyan, Liu Siying, Liu Xu, Liu Hong. Effect of ellagic acid on learning and memory ability in mice with Alzheimer's disease and its molecular mechanism [J]. Shandong Medicine, 2019,60(35):38-41.

[25] Espin Juan Carlos et al. Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans.[J]. Journal of agricultural and food chemistry, 2007, 55(25): 10476-10485.

[26] Bo Hongwei, Cheng Jun, Yang Liu, Jiang Yichen, Cao Qingqin, Zhang Qing, Qin Ling. Antioxidant and bacteriostatic effects of male flower sequence extract of chestnut [J]. Scientia Silvae Sinicae, 2015, 51(05):145-152.

[27] Sampaio ADG, Gontijo AVL, Lima GMG, de Oliveira MAC, Lepesqueur LSS, Koga-Ito CY. Ellagic Acid-Cyclodextrin Complexes for the Treatment of Oral Candidiasis. Molecules. 2021 Jan 19; 26 (2) : 505.