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Academic Journal of Medicine & Health Sciences, 2024, 5(2); doi: 10.25236/AJMHS.2024.050208.

Research Progress on Anti-inflammatory, Antioxidant, and Bone Metabolism Regulating Effects of Punicalagin

Author(s)

Tuerxunguli Kahar1, Alida Yumubieke2, Gulinuer Awuti3

Corresponding Author:
Tuerxunguli Kahar
Affiliation(s)

1Department of Periodontal Mucosa, the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, China

2Department of Periodontal Mucosa, the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, China

3Department of Periodontal Mucosa, the First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, China

Abstract

A large body of epidemiological evidence in the scientific community emphasizes that proprietary Chinese patent medicine can reduce the prevalence of common diseases such as diabetes, cardiovascular disease, cancer and stroke. The therapeutic effect of Chinese patent medicine is partly explained by phenolic secondary metabolites or polyphenolic compounds. Therefore, polyphenols are widely found in plants and have antioxidant and anti-inflammatory effects. In addition, polyphenol compounds have natural biocompatibility and safety, and are harmless to human body. Punicalagin makes up half of the pomegranate fruit and has more pronounced antioxidant and anti-inflammatory properties than the rest of the fruit. And the most important active ingredient in pomegranate peel, found only in this plant, is Punicalagin. These polyphenolic compounds in pomegranate peel are known to have the most dramatic therapeutic effects. Several studies have shown that Punicalagin has anti-inflammatory, antioxidant, antibacterial, antiviral and other effects. However, despite extensive research in recent years, a review of the data shows that there is insufficient evidence to support the therapeutic effects of polyphenol compounds in pomegranate peel. In this review, the research progress of antiinflammation, antioxidation and regulation of bone metabolism of angarnet was reviewed.

Keywords

Punicalagin, anti-inflammatory, antioxidant, bone metabolism

Cite This Paper

Tuerxunguli Kahar, Alida Yumubieke, Gulinuer Awuti. Research Progress on Anti-inflammatory, Antioxidant, and Bone Metabolism Regulating Effects of Punicalagin. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 2: 50-53. https://doi.org/10.25236/AJMHS.2024.050208.

References

[1] Rojanathammanee L, Puig KL, Combs CK. Pomegranate polyphenols and -extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease[J]. JNutr, 2013,143(5): 597-605.

[2] Wang Youxin, Peng Luyuan. Protective effect of punicalagin on lipopolysaccharide induced damage to chicken glandular gastricepithelial cells [J]. Chinese Journal of Veterinary Medicine, 2023.3.12, 45(5).

[3] Holle beeck S, Win and JHerent MF, et al. inflammatory effects 'of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2cells, an in vitro model of human intestine [J].Food Funct,2012,3(8)875-885. 

[4] Feng X, Yang Q, Wang C, Tong W, Xu W. Punicalagin exerts protective effects against ankylosing spondylitis by regulating NF-kappaB-TH17/JAK2/STAT3 signaling and oxidative stress. Biomed Res Int. 2020; 2020:4918239.

[5] Huang Mingcheng, Wu Keping, Zeng Shan et al. Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis.[J] .J Inflamm Res, 2021, 14: 1901-1913.

[6] Cao Y, Chen J, Ren G. Punicalagin Prevents Inflammation in- LPS--Induced RAW264.7-Macrophages by-Inhibiting FoxO3a/ Autophagy Signaling-Pathway-[J] Nutrients, 2019, 11(2794). 

[7] Marques, L.C.; Pinheiro, AJ, Arauj0, J.G.,de Oliveira, RA., Silva, S.NAbreu, IC. de Sousa, E.M, Femnandes, E.S., Luchessi, AD. Silbiger, VN., et al ·Anti- Inflammatory Effects of a Pomegranate Leaf Extract in LPS-Induced Peritonitis. Planta Medica 2016, 82, 1463-1467.

[8] Fouad AA, Qutub HO, A1-Melhim WN. Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide [J]. Environ Toxicol Pharmaco1, 2016, 45:158- 162. 

[9] Rao F, Tian H, Li W, et al. Potential role of punicalagin against oxidative stress induced testicular damage]J]. Asian- JAndro 1, 2016,18(4)627-632. 

[10] Banihani S, Swedan S, Alguraan Z. Pomegranate and type 2 diabetes [J]. Nutr Res, 2013,33(5):341-348.

[11] Lee SI,Kim BS Kim KS,et al. Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochem Biophys Res Commun.2008; 371(4):799-803. 

[12] Ramage SC, Urban NH, Jiranek WA, et al. Expression of RANKL in osteolytic membranes. association with fibroblastic-cell markers. JBone Joint Surg Am. .2007 89(4):841-848. 

[13] Jean-Gilles DLi L,Vaidyanathan- VG,et al. Inhibitory effects of polyphenol unicalagin on type-Il collagen degradation in vitro and inflammation in vivo. Chem Biol Interact. 2013: 205(2):90-99. 

[14] Kim YH, Choi EM. Stimulation of osteoblastic differentiation and inhibition of interleukin-6and nitric-oxide imn MC3T3-E1 cells by pomegranate ethanol extract. Phytother Res. 2009, 23(5):737-739.