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Academic Journal of Medicine & Health Sciences, 2024, 5(3); doi: 10.25236/AJMHS.2024.050308.

Advances in the pathogenesis of traumatic temporomandibular joint ankylosis


Mi Na, Yao Zhitao

Corresponding Author:
Yao Zhitao

School of Stomatology, Xinjiang Medical University, Urumqi, China


Temporomandibular joint (TMJ) is a synovial joint composed of condyle, articular disc, temporal fossa and other structures. TMJ is prone to joint diseases due to its frequent activities and bite force. Temporomandibular joint ankylosis (TMJA) is a serious joint disease, which can lead to fibrous adhesion or bone adhesion within the joint, affect mandibular movement and cause facial deformity. Previous studies have shown that trauma, infection, systemic diseases and other causes can cause TMJA, among which trauma factors account for about 90%. The pathogenesis of traumatic TMJA is complex, treatment is difficult and there is a certain recurrence rate. However, the pathogenesis of traumatic TMJA has not been truly revealed, and animal model studies vary. In this article, the related factors and pathogenesis of traumatic TMJA were discussed.


Traumatic temporomandibular joint ankylosis, Incidence related factors, pathogenesis

Cite This Paper

Mi Na, Yao Zhitao. Advances in the pathogenesis of traumatic temporomandibular joint ankylosis. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 3: 42-48. https://doi.org/10.25236/AJMHS.2024.050308.


[1] Yuan Xihang, Lu Changsheng. Treatment progress of temporomandibular joint ankylosis [J]. Chinese Medical Cosmetics, 2018,8(03):80-87

[2] Prechel U, Ottl P, Ahlers OM, et al. The treatment of temporomandibular joint dislocation. Dtsch Arztebl Int 2018; 115: 59-64. 

[3] Xiao E, Zhao Lu, Zhang Yi. Etiology and treatment of traumatic temporomandibular joint ankylosis [J]. Chinese Journal of Applied Stomatology, 2017, 10(03):146-152.

[4] Resnick CM. Temporomandibular Joint Reconstruction in the Growing Child. Oral Maxillofac Surg Clin North Am. 2018 Feb; 30(1):109-121.

[5] Gu Jiana, Jiao Boqiang, Li Zhiyong. Research progress on the etiology of anterior disc displacement of temporomandibular joint [J]. Stomatology, 2012, 42(10):942-945. 

[6] Xia L, Zhang Y, An J, et al. Evaluating the remodeling of condyles reconstructed by transport distraction osteogenesis in the treatment of temporomandibular joint ankylosis. J Craniomaxillofac Surg. 2020 May;48(5):494-500.

[7] Ning Y,Wang X,Lammi MJ,et al. Changes in the NF- κB signaling pathway in juvenile and adult patients with Kashin-Beck disease[J]. Exp Cell Res, 2019, 379(2):140-149.

[8] Meng F, Liu Y, Hu K, et al. A comparative study of the skeletal morphology of the temporo-mandibular joint of children and adults [J]. J Postgrad Med, 2008, 54(3):191-194

[9] Duan DH, Zhang Y. A clinical investigation on disc displacement in sagittal fracture of the mandibular condyle and its association with TMJ ankylosis development [J]. Int J Oral Maxillofac Surg, 2011, 40(2):134-138.

[10] Sarma UC, Dave PK. Temporomandibular joint ankylosis: An Indian experience [J]. Oral Surg Oral Med Oral Pathol, 1991, 72(6):660-664.

[11] Guo Jun, Fei Wei, LI Qing-hua. An animal study on the outcome mechanism of traumatic temporomandibular joint ankylosis [J]. International J Stomatology, 2019, 46(01):12-19.

[12] Jiang Xin, HU Kaijin. Prevention of traumatic temporomandibular joint ankylosis [J]. Chin J Practical Stomatology, 2013, 6(03):132-135. 

[13] Deng TG, Liu CK, Wu LG, et al. Association between maximum mouth opening and area of bony fusion in simulated temporomandibular joint bony ankylosis[J]. Int J Oral Maxillofac Surg, 2020, 49(3): 369⁃376. 

[14] Yan Y, Zhang Y, Sun Z, et al. The relationship between mouth opening and computerized tomographic features of posttraumatic bony ankylosis of the temporomandibular joint[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 111(3): 354-361.

[15] Yang Cheng, SUN Moyi, Yang Yaowu et al. Treatment of condylar fracture in children with open plate fixation. J Practical Stomatology, 2003; 19(6):620-632

[16] Zavodovskaya R, Vapniarsky N, Garcia T, et al. Intra ⁃ and extra ⁃ articular features of temporomandibular joint ankylosis in the cat (felis catus)[J]. J Comp Pathol, 2020, 175: 39⁃48. doi: 10.1016/j.jc⁃pa. 2019.12.006.

[17] Deng Tiange, Liu Ping, Liu Changkui et al. Pathological role of lateral pterygoid muscle in traumatic temporomandibular joint ankylosis [J]. Stomatology Research,2021,37(05):442-447.

[18] Fan-Wen Meng et al. A new hypothesis of mechanisms of traumatic ankylosis of temporomandibular joint[J]. Medical Hypotheses,2009,73(1):92-93. 

[19] Mei Jie, Jiang Yangmei, Li Yunfeng et al. Treatment of temporomandibular joint ankylosis and its secondary deformities in children [J]. Stomatology Research,2018,34(03):274-277.

[20] Arakeri G, Kusanale A, Zaki GA, et al. Pathogenesis of post-traumatic ankylosis of the temporomandibular joint: A critical review[J]. Br J Oral Maxillofac Surg, 2012, 50(1):8-12.

[21] Hall MB. Condylar fractures: Surgical management [J]. J Oral Maxillofac Surg, 1994, 52(11): 1189-1192.

[22] Gu S, Wei N, Yu L, et al. Shox2-defi ciency leads to dysplasia and ankylosis of the temporomandibular joint in mice[J]. Mech Dev, 2008, 125(8):729-742.

[23] Dong L,Su N,Miao KS,et al. PI3K/Akt and caspase path⁃ways mediate oxidative stress-induced chondrocyte apoptosis[J]. Cell Stress Chaperones, 2019, 24(1):195-202.

[24] Liu Ziwei, Shi Quan, Wang Situo et al. Advances in the application of mesenchymal stem cell-derived exosomes in dentistry [J]. Chin J Gerontology, 2012,20(03):174-178.

[25] Yan YB, Zhang Y, Gan YH, et al. Surgical induction of TMJ bony ankylosis in growing sheep and the role of injury severity of the glenoid fossa on the development of bony ankylosis. J Craniomaxillofac Surg. 2013 Sep; 41(6):476-486.

[26] Ma D, Zhang S, Pang C, et al. The Application of intraoperative computed tomography in surgical management of temporomandibular joint ankylosis[J]. J Oral Maxillofac Surg, 2021, 79(1): 90.e1⁃ 90.el.

[27] Myrto Bami et al. Superiority of synovial membrane mesenchymal stem cells in chondrogenesis, osteogenesis, myogenesis and tenogenesis in a rabbit model[J]. Injury,2020,51:2855-2865

[28] Zheng Weiwei, Yang Min, WU Cheng et al. Experimental study on osteogenic properties of synovial mesenchymal stem cells in vitro and in vivo [J]. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(01):102-109.

[29] Jiang Xin, Li Jinchao, DOU Chunbo et al. The role of synovial mesenchymal stem cells in traumatic temporomandibular joint ankylosis [J]. J Clin Stomatology,2021,37(11):651-654.

[30] He LH, Liu M, He Y, et al. TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation. Sci Rep. 2017 Feb 22;7:42385. 

[31] Muire PJ, Mangum LH, Wenke JC. Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds. Front Immunol. 2020 Jun 4;11:1056. 

[32] Wang X, Chen X, Lu L, et al. Alcoholism and Osteoimmunology. Curr Med Chem. 2021; 28(9):1815-1828. 

[33] Xia L, Zhang Y, An J, et al. Evaluating the remodeling of condyles reconstructed by transport distraction osteogenesis in the treatment of temporomandibular joint ankylosis[J]. J Craniomaxillofac Surg, 2020, 48(5): 494⁃500. 

[34] Zhao L, Xiao E, He L,et al. Reducing macrophage numbers alleviates temporomandibular joint ankylosis. Cell Tissue Res. 2020 Mar; 379(3):521-536. 

[35] Shi Mei-xia, GAO Jing, XU Yan-hua. Research progress on gene regulation of growth and remodeling of mandibular condylar cartilage [J]. Medicine Review,2018,24(06):1052-1056+1061.

[36] Xu Wei, Liu Da, Wang Wei et al. Research status of autophagy in the pathogenesis and treatment of osteoarthritis [J]. Chin J Orthopedics, 2021, 30(10):902-905+910.

[37] Xia L, An J, He Y, et al. Association between the clinical features of and types of temporomandibular joint ankylosis based on a modified classification system. Sci Rep. 2019 Jul 19; 9(1): 10493. 

[38] Hu SL, Zhang CW, Ni LB, et al. Stabilization of HIF-1α alleviates osteoarthritis via enhancing mitophagy [J]. Cell Death Dis, 2020, 11 (6): 481.

[39] Duan R, Xie H, Liu ZZ. The role of autophagy in osteoarthritis [J].Front Cell Dev Biol, 2020, 8: 608388.

[40] Hu Kai-jin, Ma Zhen, WANG Yiming, et al. New progress in the pathogenesis of traumatic temporomandibular joint ankylosis [J]. Prevention and Treatment of Stomatology, 2021, 29(12): 793-800.

[41] Liang SX, Wang HL, Zhang PP, et al. Differential regulation of blood vessel formation between traumatic temporomandibular joint fibrous ankylosis and bony ankylosis in a sheep model. J Craniomaxillofac Surg. 2019 Nov;47(11):1739-1751. 

[42] Vincent AG, Ducic Y, Kellman R. Fractures of the mandibular condyle[J]. Facial Plast Surg, 2019, 35(6): 623⁃626. 

[43] Wang L,Gai P, Xu R, et al. Shikonin protects chondrocytes from interleukin-1beta-induced apoptosis by regulating PI3K/Akt signaling pathway[J]. Int J Clin Exp Pathol, 2015, 8(1):298-308

[44] Zhang J, Sun X, Jia S, et al. The role of lateral pterygoid muscle in the traumatic temporomandibular joint ankylosis: A gene chip based analysis. Mol Med Rep. 2019 May; 19(5):4297-4305. 

[45] Pilmane Mara, Skagers Andrejs. Growth factors, genes, bone proteins and apoptosis in the temporomandibular joint (TMJ) of children with ankylosis and during disease recurrence.[J]. Stomatologija, 2011, 13(3): 96-101.

[46] Duan D, Li J, Xiao E, et al. Histopathological features of hypertrophic bone mass of temporomandibular joint ankylosis (TMJA): An explanation of pathogenesis of TMJA. J Craniomaxillofac Surg. 2015 Jul; 43(6):926-933.