Academic Journal of Medicine & Health Sciences, 2024, 5(4); doi: 10.25236/AJMHS.2024.050409.
Wang Haixia1, Dai Yinhai2, Yang Yifan3, Peng Tao1, Yan Yongmei3, Wang Tao4
1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
3Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712046, China
4Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China
Thrombotic diseases have high disability rates, high mortality rates, and seriously endanger human health and safety. Platelets play an important role in the process of thrombus formation. Salvia miltiorrhiza has been widely recognized in clinical practice both domestically and internationally for its ability to promote blood circulation, remove blood stasis, antioxidant, and anti-platelet aggregation, and anti-atherosclerosis effects. Due to the multi-component, multi-pathway, and multi-target characteristics of the anti-platelet aggregation mechanism of Salvia miltiorrhiza, the specific signal transduction pathway has become a hot and difficult research topic in studying the pharmacological mechanism of Salvia miltiorrhiza. Based on the latest literature, this article reviews the targets and pathways of the modern pharmacological mechanism of Salvia miltiorrhiza extract in anti-platelet aggregation, providing new ideas for the research of safer and more effective anti-platelet aggregation drugs.
thrombotic diseases; salvia miltiorrhiza extract; anti-platelet aggregation; thrombosis; signaling pathway
Wang Haixia, Dai Yinhai, Yang Yifan, Peng Tao, Yan Yongmei, Wang Tao. Research Progress on the Mechanism of Salvia Miltiorrhiza Extract Inhibiting Platelet Aggregation. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 4: 64-70. https://doi.org/10.25236/AJMHS.2024.050409.
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