Frontiers in Medical Science Research, 2024, 6(4); doi: 10.25236/FMSR.2024.060404.
Guojuan Shi1,2, Jian Yang1,3, Anghui Peng1, Ruiqi Wang1, Yihao Sun1
1Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, 519000, China
2Department of Nephrology, Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, China
3Department of Respiratory and Critical Care Medicine, Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, China
Cancer is one of the major diseases affecting human health, and statistics show that about 90% of cancer patients die from tumor migration rather than primary tumor growth. The mechanism of tumor migration is still unclear, and most of the current studies are in vitro cell experiments, which can not fully reflect the real situation in vivo, so it is particularly important to use in vivo models for research. In vivo models of Drosophila melanogaster, we found that Tip60 inhibited cell migration induced by down-regulating the cell polar gene scrib and tumor invasion induced by lgl-/-/RasV12. However, the deletion of acetyltransferase activity in Tip60 can induce cell migration through activation of JNK signaling pathway. We found that Tip60 inhibited JNK signals-mediated cell migration and tumor invasion through the acetylation of downstream transcription factor Fos, and inhibited the expression of downstream migration molecules such as MMP1. In this study, the role of Tip60-Fos in cell migration and tumor invasion was investigated, and the molecular mechanism of Tip60-Fos was elucidated, and corresponding validation was carried out in the samples of kidney cancer patients. These studies will further improve the regulatory network of tumor migration and provide new ideas for the treatment and drug target research of kidney cancer.
Kidney Renal Clear Cell Carcinoma (KIRC), Drosophila melanogaster, JNK signal, Tip60, Fos
Guojuan Shi, Jian Yang, Anghui Peng, Ruiqi Wang, Yihao Sun. Acetyltransferase Tip60 inhibits the invasion and migration of renal cell carcinoma through JNK signaling. Frontiers in Medical Science Research (2024), Vol. 6, Issue 4: 26-38. https://doi.org/10.25236/FMSR.2024.060404.
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