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Frontiers in Medical Science Research, 2024, 6(4); doi: 10.25236/FMSR.2024.060408.

Correlation between Acid-base Environment and Coronary Artery Calcification in Maintenance Hemodialysis Patients


Xinrun Zhou, Hua Gan

Corresponding Author:
Hua Gan

Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China


Vascular calcification increases the mortality of maintenance hemodialysis patients, and the acid-base environment in maintenance hemodialysis (MHD) patients may affect the occurrence of vascular calcification. This study selected 123 MHD patients in the Department of Nephrology, the First Affiliated Hospital of Chongqing Medical University from June 2021 to June 2022. The general clinical data and laboratory indicators of the patients were collected. The coronary artery calcification score ( CACS ) of the patients was accurately calculated by collecting multi-slice CT. According to CACS, they were divided into a calcification group (CACS > 0) and a non-calcification group ( CACS = 0 ). By analyzing and comparing whether there were differences in pre-HD PH, pre-HD bicarbonate, and other laboratory indicators between the two groups, the correlation between pre-HD PH, pre-hemodialysis bicarbonate, and CACS was analyzed. Among 123 MHD patients in our hospital, 56.9% of patients had coronary artery calcification (CACS > 0), including 48.6% males, with an average age of (64.87±12.35) years old. The average pre-HD AB was 23.5(20.88,26.35). There were significant differences in age, dialysis age, pre-HD AB, pre-HD SB, pre-HD CO2, serum calcium, and serum creatinine between the calcification group and the non-calcification group (P < 0.05), while there were no significant differences in serum phosphorus, calcium and phosphorus product, and iPTH. CACS were significantly positively correlated with age(r=0.283P<0.001), pre-HD AB(r=0.187 P=0.039), pre-HD CO2 (r=0.181 P=0.045) and serum calcium (r=0.203 P=0.003). Multivariate analysis indicated that diabetes, age, dialysis age, and serum calcium were independently associated with CACS. Metabolic acidosis and coronary artery calcification are very common in maintenance hemodialysis patients. CACS decreases with the decrease of pre-hemodialysis bicarbonate. Diabetes, age, dialysis age, and calcium are independent risk factors for coronary artery calcification in MHD patients. Therefore, we should pay attention to early medication, and control serum glucose and serum calcium, to prevent and treat vascular calcification in clinical practice.


Maintenance hemodialysis, metabolic acidosis, coronary artery calcification

Cite This Paper

Xinrun Zhou, Hua Gan. Correlation between Acid-base Environment and Coronary Artery Calcification in Maintenance Hemodialysis Patients. Frontiers in Medical Science Research (2024), Vol. 6, Issue 4: 55-61. https://doi.org/10.25236/FMSR.2024.060408.


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