Falls are the leading cause of injury and death in the elderly, and medication is one of the important adjustable factors causing falls in the elderly. It is of great significance to explore the relationship between polypharmacy and falls in the elderly. This article systematically reviews the relevant literature from three aspects: the types of polypharmacy in the elderly, the harm of polypharmacy to falls, and the management of polypharmacy, in order to provide a theoretical basis for the safe medication management of the elderly, improve the drug safety of the elderly, and reduce the occurrence of drug-related falls.

Gao Ni, Xiao Xiaojingzi. Research progress on polydrug-associated falls in the elderly. Frontiers in Medical Science Research (2024), Vol. 6, Issue 5: 9-14. https://doi.org/10.25236/FMSR.2024.060502.

[1] Bian Pingda, Qian Sufeng, Ying Qifeng, et al. Common causes of fall-related fractures in the elderly [J]. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 2014; (2): 161-2. 

[2] Lin S, Wang X, Wu GF.et al. Expert consensus on fall risk assessment in the elderly in China (draft)[J]. Chinese Journal of Geriatric Health Care Medicine, 2019, 17(04):47-48+50. 

[3] Guangdong Pharmaceutical Association. Expert consensus on the prevention and management of drug-related falls in the elderly [J]. Pharmaceutical Science Today, 2019, 29(10):649-658. 

[4] Zhao Ming. Prevalence and risk factors of falls among the elderly in communities in two regions of Zhejiang Province [D]. Zhejiang University, 2017. 

[5] Yan Yuqin, Zhang Ping. Research progress on fall risk factors and intervention countermeasures in the elderly in the community [J].Practical Geriatrics, 2018, 32(08):710-712. 

[6] Watanabe Jonathan H. Medication Use, Falls, and Fall-Related Worry in Older Adults in the United States. [J]. The Consultant pharmacist: the journal of the American Society of Consultant Pharmacists, 2016, 31(7): 385-393. 

[7] Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions.[J]. BMC Geriatr. 2017 Oct 10; 17(1):230. 

[8] Huang Yanan, Yang Xiaoxuan, Chen Xiao , et al. Research progress on fall-related drug management in the elderly [J] Chinese Journal of General Practice, 2021, 24(34):4409-4414. 

[9] Wang Jiaqing, Liu Jing, Huang Jia. Falls caused by drug use and their prevention[J].Drug Evaluation, 2012, 9(32):39-41. 

[10] Xiao Li, Li Wei, Shao Liming. Advances in anti-schizophrenia drug researchv[J].Chinese Journal of Medicinal Chemistry, 2016, 26(06):509-517. 

[11] Zhang Min, Fan Zhenwei.Research on the current status and influencing factors of psychotropic drug use in the elderly[J]. Chinese Journal of Prevention and Treatment of Endemic Diseases, 2017, 32(11):1241-1242. 

[12] Qin Zhaohui, Yu Pulin. A Study of the Relationship Between Falls and Medication in Older Adults [J].Chinese Journal of Gerontology, 2009, 29(23):3099-3101. 

[13] Li Liuxiang, Huang Minyi, Liang Jiayu. Analysis of fall-related factors and nursing countermeasures in hospitalized psychiatric patients [J]. China Practical Medicine, 2018, 13(35): 182-184. 

[14] Yu Chen and Allan Hicks and Alison E. While. Depression and related factors in older people in China: a systematic review [J]. Reviews in Clinical Gerontology, 2011, 22(1): 52-67. 

[15] Lu Jing, Feng Xiaorong, Huang Yuan, et al. Research progress on the clinical application of antidepressants in the elderly [J]. West China Journal of Pharmacy, 2018, 33(04):435-439. 

[16] Carvalho AF, Sharma MS, Brunoni AR, et al. The Safety, tolerability and risks associated with the use of newer generation antidepressant drugs: A critical review of the literature [J]. Psychother Psychosom, 2016, 85(5): 270-288. 

[17] Liu Qing, Dong Wenwei. Correlation between central nervous system medication and fall risk in the elderly [J]. Practical Drugs and Clinical Medicine, 2015, 18(02):235-237. 

[18] Johnell K, Fastbom J. Antiepileptic drug use in community-dwelling and institutionalized elderly: a nationwide study of over 1, 300, 000 older people. [J]. European Journal of Clinical Pharmacology, 2011, 67(10):1069-1075. 

[19] Niu Qian, Liu Xiaohong. Research progress on the association between antiepileptic drugs and falls in the elderly [J]. Beijing Medicine, 2021, 43(06):535-538. 

[20] Ensrud K E , Blackwell T L , Mangione C M , et al. Central nervous system-active medications and risk for falls in older women. [J]. Journal of the American Geriatrics Society, 2002, 50(10):1629–1637. 

[21] T, Masud, M, et al. Central nervous system medications and falls risk in men aged 60-75 years: the Study on Male Osteoporosis and Aging (SOMA)[J]. Age & Ageing, 2012. 

[22] Meng Weiping, Wei Hong. Investigation on the use of sedative-hypnotic drugs in the retired elderly in Fuzhou City [J]. Journal of Pharmaceutical Epidemiology, 2007(01):33-35. 

[23] Yang Y, Sun Y, Yan Y, et al. Study on the use of sedative-hypnotic drugs in elderly patients with chronic diseases in community standardized management [J]. Chinese Journal of General Practice, 2019, 22(13):1613-1617. 

[24] Liu Jia, Feng Ruijuan, Cui Xingyue, et al. Investigation on the knowledge and behavior related to the safe use of sedative-hypnotic drugs in elderly patients in outpatients[J]. Journal of Nursing, 2016, 23(18):56-58. 

[25] Lin Jianyu, Zhang Ying, Sun Chao, et al. Analysis and countermeasures of the causes of falls caused by sedative-hypnotic drugs in elderly patients during hospitalization[J]. Chinese Journal of Geriatrics, 2017, 36(06):627-631. 

[26] Neutel CI, Hirdes JP, Maxwell CJ, et al. New evidence on benzodiazepine use and falls: the time factor[J]. Age Ageing. 1996 Jul; 25(4):273-278. 

[27] Neutel CI, Perry S, Maxwell C. Medication use and risk of falls[J]. Pharmacoepidemiol Drug Saf. 2002 Mar; 11(2):97-104. 

[28] CHARLESWORTH C J, SMIT E, LEE D S H, et al. Polypharmacy among adults aged 65 years and older in the United States:1988—2010[J]. J Gerontol A Biol Sci Med Sc, 2015, 70(8):989-995. 

[29] Wang Ru, Guo Daihong, Li Yuanyuan, et al. Investigation and analysis of polypharmacy treatment in outpatient elderly patients[J]. Chinese Journal of Drug Application and Monitoring, 2018, 15(04): 223-226. 

[30] Li Li, Li Sha, Wei Yun et al. A systematic review of the polypharmacy rate and related factors among the elderly in the community[J]. Chinese Journal of General Practice, 2021, 24(25):3161-3170. 

[31] Zhang Fei, Li Minglin, Wang Yifei, et al. Research progress on the relationship between polypharmacy and depression in the elderly[J]. Practical Geriatrics, 2023, 37(03):226-229. 

[32] A, PATEL R, EBRAHIM S. Association between falls in elderly women and chronic diseases and drug use:cross sectional study[J]. BMJ, 2003, 327(7417):712-717. 

[33] VIEIRA E R, PALMER R C, CHAVES P H. Prevention of falls in older people living in the community[J]. BMJ, 2016, 353: i1419. DOI:10. 1136/bmj. i1419. 

[34] Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society. Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons [J]. J Am Geriatr Soc, 2011, 59(1):148-157. 

[35] Zhou Baiyu, Yu Pulin. A Study of Fall Assessment Tools in Older Adults[J] Chinese Journal of Geriatrics, 2006(03):224-227. 

[36] Song Mi, Pi Hongying, Xu Yue, et al. Research on fall assessment tools for the elderly [J]. China Medical Herald, 2020, 17(34):60-63. 

[37] Avin K G, Hanke T A, Kirk-Sanchez N, et al. Management of falls in community-dwelling older adults: Clinical guidance statement from the academy of geriatric physical therapy of the american physical therapy association[J]. Physical Therapy, 2015, 95(6): 815-834. 

[38] Huang Lianjiao, Chen Zhiqing, Qin Zhihui. Application of project management team in reducing patients falling caused by high-risk drugs[J]. Nursing Practice and Research, 2016, 13(18):128-130. 

[39] Qin Zhaohui, Yu Pulin, Wu Zhengyi. Current situation and progress of fall research in the elderly [J]. Chinese Journal of Geriatrics, 2005(09):711-714. 

[40] Zhang Qi. Effect of clinical pharmacists on pharmaceutical intervention in the management of clinical irrational drug use[J] Continuing Medical Education, 2022, 36(02):97-100. 

[41] Wang J, Chen Z, Song Y. Falls in aged people of the Chinese mainland: Epidemiology, risk factors and clinical strategies [J]. Ageing Research Reviews, 2010, 9(supp-S):S13-S17. 

[42] Guidelines for the intervention of falls in the elderly at home (nursing)[J]. Chinese Journal of Geriatric Health Care Medicine, 2018, 16(03):32-34. 

[43] Larsson TJ, Hgvide ML, Svanborg M, et al. Falls prevention through community intervention-a swedish example[J]. Safety Sci, 2009:48(2):204-208. 

[44] Zhang Chun. Investigation and intervention evaluation of the prevention of falls among the elderly in a university community in Guangzhou[J]. Modern Hospital, 2013: 13(9):152-154. 

[45] Tao Yanling, Chen Juanhui, Guan Yumei, et al. Risk factors and preventive measures for falls in the elderly at home in the community[J]. Chinese Journal of Nursing Management, 2017, 17(7): 910-914. 

[46] Ye Linxiao, Deng Yinghong, Zhang Min. Investigation on the causes of falls and their perception of fall prevention in elderly patients[J]. Jilin Medical Journal, 2013, 34(16):3196-3197. 

[47] Feng Lei, Li Yunshu, Yang Jie, et al. Effect of virtual reality-based somatosensory game integrated into home dialysis exercise management on fall risk and quality of life of dialysis patients [J]. China Blood Purification, 2021, 20 (05): 302 -305+332.