In recent years, the rapid development of bio-3D printing technology has brought great changes and breakthroughs to the medical field. Biological materials and cells can be assembled in an orderly manner according to a specific structure and composition through bio-3D printing technology, so as to achieve the manufacture of highly customized artificial organs and tissues. The emergence of this technology not only provides a new treatment for patients with tissue and organ damage, but also provides a new experimental model for the development of medical research and biological science. The heart is one of the most important organs in the human body, which is of great significance for the simulation and drug development of heart diseases. Over the past three decades, there have been significant advances in bioprinting research and applications for the heart. Through a deep understanding of the structure and function of the heart, combined with the advantages of bioprinting technology, in vitro simulation of the heart can be achieved. The purpose of this paper is to review the research and application of bio-3D printed heart in the past 30 years, in order to provide reference for related.

Hanlin Wang. Progress of 3D bioprinting of heart tissue. Academic Journal of Medicine & Health Sciences (2024), Vol. 5, Issue 6: 37-44. https://doi.org/10.25236/AJMHS.2024.050606.

[1] Ruan Changshun and Pan Haobo's research team 3D printed a mechanically stable non-calcium ion cross-linked alginate-based scaffold [J]. Integrated Technology,2020.

[2] Jiang Y N. Preparation of grass-derived nanocelluloses composite gelatin and study on the forming process of bio-3D printing skin scaffold [D]. Yangzhou University,2018.

[3] Zhang P.Synthesis of BaYbF_5:Tm@BaGdF_5:Yb,Tm nuclear/shell nanocomposites and its multimodal imaging (fluorescence /CT/MRI) study [D]. Jilin University,2016.

[4] Chen Lei. Research on Video sequence Face image segmentation and recognition technology [D]. Soochow University, 2014.

[5] Wang Kai, Zheng Shuang, Pan Su, Zhang Heng, Zhang Wei, WANG Haosheng, Yang Xiaoyu, Fu Chuan. Characteristics of 3D printed bone tissue engineering scaffolds for repairing bone defects [J]. China Tissue Engineering Research, 2019.

[6] Mironov V, Reis N, Derby B. Review:bioprinting:a beginning[J].Tissue Eng, 2006, 12(4): 631-4. 

[7] Murphy S V, Atala A. 3D bioprinting of tissues and organs[J]. Nat Biotechnol, 2014, 32(8):  773-788. DOI:10.1038/nbt.2958

[8] QIU Guixing, Ding Wenjiang, Tian Wei, Qin Ling, Zhao Yu, Zhao Yu, Lu Jian, Chen Daijie, Yuan Guangyin, Wu Chengtie, Lu Bingheng, Du Ruxu, Chen Jiming,Mo Elbestawi, Gu Zhongwei, Li Dichen, Sun Wei, Zhao Yuanjin, He Jie, Jin Dadi, Liu Bin, Zhang Kai, Li Jianmo,Kam W.Leong, ZHAO Dewei, HAO Dingjun, AO Yingfang, Deng Xuliang, Yang Huilin, Xu Shaoke, Chen Yingqi, Li Long, FAN Jianping, NIE Guohui, Chen Yun, Zeng Hui, Chen Wei, LAI Yuxiao. Medical Additive Manufacturing: From cutting-edge technology to Product development [J].Engineering,2020.

[9] Ju Ernan, Wu Yi, Li Xinxin, Guan Tianmin, Chen Yong, Du Yuhuan. Research and application of 3D printing in biomedical field [J]. China Tissue Engineering Research,2018

[10] Wu Chong, Leng Xuehui. Technical problems and prospects of 3D bioprinting in tissue engineering [J]. Shanxi Science and Technology, 2020.

[11] ZHANG P. Application status of 3D printing in biomedicine [J]. New Materials Industry,2017. (in Chinese).

[12] Yang Runhuai, Chen Yueming, Ma Changwang, Wang Huiqin, Wang Shuzhen h. Advances in 3D printing technology and materials for biological cells [J]. Journal of Biomedical Engineering,2017.

[13] Cai C. Study on the mechanism of atrial ventricular valve development abnormality caused by tnni1b gene knockout in Zebrafish [D]. Huazhong University of Science and Technology,2018.

[14] Wang Shihao. Research on Human cardiovascular Virtual reality system Modeling and model manufacturing technology [D]. Chongqing University, 2016.

[15] Du Xianbin, Xu Mingen, Wang Ling, Zhou Yongyong. 3D liver tissue bioprinting based on coaxial flow technology [J]. Chinese Journal of Biomedical Engineering, 2018.