Frontiers in Medical Science Research, 2024, 6(7); doi: 10.25236/FMSR.2024.060707.
Xi Lv1, Yiming Ma2, Yiran Diao1, Danyan Liu3
1Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, Hebei, 050000, China
2Department of Ophthalmology, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, 510000, China
3Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
Backgroud Glaucoma is a group of irreversible blindness caused by retinal nerve fiber layer defect and visual field defect.Optical coherence tomography angiography(OCTA)can be used to observe optic disc vessels noninvasively.It is important for early diagnosis and follow-up of glaucoma to clarify the correlation between the density of optic disc capillary network and other observational indicators of glaucoma optic nerve damage.Objective By using optical coherence tomography angiography,clarify the correlations among optic disc capillary network density and retinal nerve fibre layer(RNFL)thinkness and mean deviation(MD)of visual field and mean cup disc ratio in primary glaucoma.To explore the role of this technique in the early diagnosis of glaucoma and monitor of the condition of the disease.Methods In this study,we collected 97 eyes of 61 subjects diagnosed with primary glaucoma.acute angle closure glaucoma group has 45 eyes of 31 case,chronic angle closure glaucoma group has 24 eyes of 14 case,primary open angle glaucoma group has 28 eyes of 16case.The image of optic disc capillary network,RNFL thickness and mean cup disc ratio were collected by OCTA.Image J was used to calculate the capillary network density in the cup disc image,and the mean deviation was obtained by using the full automatic perimeter to detect the visual field.Results Acute angle-closure glaucoma group:the optic disc capillary network density was 0.13±0.07%,RNFL thickness was 104.04±14.00μm,MD was 8.68±6.52dB,the mean cup disc ratio was 0.57±0.19;chronic angle-closure glaucoma group:the optic disc capillary network density was 0.12±0.06%,RNFL thickness was 104.08±17.12μm,MD was 7.05±6.37dB,the mean cup disc ratio was 0.57±0.20;primary open angle glaucoma group:the optic disc capillary network density was 0.15±0.05%,RNFL thickness was 111.71±9.16μm,MD was 5.30±4.37dB,the mean cup disc ratio was 0.53±0.16.Significant positive correlations were found between optic disc capillary network density and optic disc RNFL thickness(P<0.05),significant negative correlations were found between optic disc capillary network density and MD and mean cup disc ratio(P<0.05)by pearson correlations text in three group.Conclusions There is a clear correlation between optic disc capillary network density and optic disc RNFL thickness and MD and mean cup disc ratio in patients with primary glaucoma,the optic disc capillary network density can be used as reference for the diagnosis and follow-up of primary glaucoma.
Glaucoma, Optical coherence tomography angiography, Optic disc capillary network density, Optic disc RNFL thickness, MD, Mean cup disc ratio
Xi Lv, Yiming Ma, Yiran Diao, Danyan Liu. The application of optic disc capillary network density in the diagnosis and follow-up of primary glaucoma by optical coherence tomography angiography. Frontiers in Medical Science Research (2024), Vol. 6, Issue 7: 63-68. https://doi.org/10.25236/FMSR.2024.060707.
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