Frontiers in Medical Science Research, 2024, 6(10); doi: 10.25236/FMSR.2024.061007.
Ye Wang1, Fu Wang2
1Dental Hospital Affiliated to the School of Oral Medicine of Dalian Medical University, Dalian Medical University, Dalian, China
2Dental Hospital Affiliated to the School of Oral Medicine of Dalian Medical University, Dalian Medical University, Dalian, China
Chronic Periodontitis (CP) is one of the most common chronic inflammatory diseases, caused by an oral flora imbalance, which leads to systemic chronic inflammation. Alzheimer's disease (AD), commonly referred to as 'senile dementia', is one of the most prevalent neurodegenerative diseases with an unknown etiology and latent onset in the elderly, posing a significant health challenge in aging societies. Epidemiological evidence indicates a correlation between CP and AD, and effective periodontal basic treatment can reduce the risk of AD to some degree. Current studies primarily suggest that CP may induce AD by amplifying neuroinflammation through systemic chronic inflammation or by direct invasion of CP-related pathogens into the brain, but the specific mechanism remains unclear, and there is a shortage of effective tools for early diagnosis of both diseases. Therefore, this paper summarizes the correlation studies between CP and AD and the possible mechanism of action, and emphasizes the feasibility of saliva as a biomarker of these two diseases, with a view to providing possible ideas for the early prevention and treatment of CP and AD.
chronic periodontitis; Alzheimers disease; neuroinflammation; Porphyromonas gingivalis; saliva
Ye Wang, Fu Wang. Correlation of Chronic Periodontitis with Alzheimer's Disease and Research Progress on Salivary Biomarkers. Frontiers in Medical Science Research (2024), Vol. 6, Issue 10: 45-48. https://doi.org/10.25236/FMSR.2024.061007.
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