Childhood asthma is a complex multifactorial disease whose pathogenesis is influenced by a combination of genetics and environmental factors. In recent years, there has been a gradual increase in studies on the interaction between genetic susceptibility and environmental exposures, revealing how the two work together in the development and progression of asthma. The aim of this study was to investigate the genetic basis of childhood asthma and the influence of environmental factors, and to analyze the mechanism of their interaction. By reviewing relevant literature and clinical studies, this paper summarizes the discovery of asthma susceptibility genes and the influence of environmental factors on asthma development. The study also discusses the potential application of gene-environment interaction modeling in the prediction and treatment of childhood asthma. Finally, the paper points out the challenges in current research and future research directions, especially how to achieve individualized prevention and treatment strategies through precision medicine. Through a deeper understanding of the interaction between genetics and environmental factors in childhood asthma, it is expected to provide a new theoretical basis and practical guidance for the early diagnosis and intervention of this disease.

Xinyi Wang, Yiran Zhang. Analysis of Genetics-Environmental Factors Interaction in Childhood Asthma. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 1: 26-31. https://doi.org/10.25236/IJFM.2025.070105.

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