Cerebral small vessel disease (CSVD) encompasses a spectrum of clinical, imaging, and pathological alterations resulting from diverse cerebrovascular pathologies affecting arteries, arterioles, capillaries, and venules. As a primary etiology of lacunar infarcts, white matter hyperintensities, and vascular injury, CSVD typically manifests as acute stroke, cognitive impairment, neuropsychiatric symptoms, and motor disorders. Early clinical detection remains challenging due to non-specific presentations, often leading to delayed diagnosis until symptom onset. Prognosis is generally unfavorable, significantly compromising functional independence. Proactive screening and intervention may decelerate progression and enhance quality of life. This review synthesizes contemporary research on correlations between total imaging burden and cognitive deficits, motor dysfunction, affective disorders, voiding dysfunction, and dysphagia, offering actionable insights for early CSVD diagnosis/management while advancing innovative diagnostic and preventive paradigms.

He Lingyun, Bai Xiaomei, Cheng Xianglin. Research Progress on the Correlation between the Total Imaging Load and the Damage Caused by Cerebral Small Vessel Disease. Frontiers in Medical Science Research (2025), Vol. 7, Issue 6: 15-21. https://doi.org/10.25236/FMSR.2025.070602.

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