This study evaluates the efficacy of Korean Red Ginseng Formula Tablet (KRGT) in reducing blood lipid levels through a human feeding trial. A previous study identified the KRGT, which improves blood lipids, by studying human hepatocellular carcinoma (HepG2) cells and animal models[1]. This randomized, double-blind, placebo-controlled trial lasted 60 days. In total, 113 participants who passed the health assessments were randomly assigned to either the trial or placebo group based on their blood lipid levels. The trial group received KRGT, whereas the control group received a placebo, with both groups taking four tablets twice daily. Changes in serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were observed pre and post-intervention.The study observed no adverse changes in the mental state, sleep, diet, or bowel movements of the participants before and after the intervention. Blood tests, urinalysis, stool analysis, and blood biochemistry results were normal in both groups throughout the study period. After 60 days, the trial group exhibited significant reductions in TC, TG, and LDL-C levels compared with baseline (P<0.01). Moreover, compared with the placebo group, the trial group showed significant decreases in serum TC, TG (P<0.01), and LDL-C levels (P<0.05), with no significant difference in HDL-C levels (P>0.05). The total efficacy rate in the trial group was 25.5%, which was significantly higher than that in the placebo group (P<0.01). KRGT demonstrated clear lipid-regulating effects in humans and was well tolerated. This study confirmed the safety of KRGT and provided valuable insights into its mechanism of action in blood lipid regulation.There are numerous clinical and animal experiments proving the lipid-lowering effects of red ginseng, Crataegus Fructus and Cassiae Semen, but there has been no research on the lipid-lowering effects of this compound yet.

Ping Zheng, Yunting Hong, Ming Zhang, Huijuan Xiao, Jing Li, Yi Yang. Safety and Hypolipidemic Efficacy of Korean Red Ginseng Formula Tablet: A Randomized, Double-Blind and Placebo-Controlled Clinical Trial. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 4: 85-93. https://doi.org/10.25236/IJFM.2025.070411.

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