Academic Journal of Materials & Chemistry, 2025, 6(3); doi: 10.25236/AJMC.2025.060314.
Baoyi Chen1, Ling Hao2
1International School on the Rhine, Neuss, 41464, Germany
2Shenzhen MSU-BIT University, Shenzhen, 518172, China
Astellolide R, a juniperane-type sesquiterpenoid with the molecular formula C₁₅H₁₈O₄, is a rare and structurally intricate natural product especially distinguished by its cage-like pentacyclic structure, dioxabicycloheptane moiety, multiple ether linkages, and five carbon stereocenters. These highly unusual features contribute to both its distinctive reactivity and potential biological significance, while posing formidable challenges for synthetic access. Another factor that makes the access as well as studies in this area more challenging is due to Astellolide R being previously discovered not so long ago. In this study, we conducted a retrosynthetic and synthetic analysis of three distinct pathways aimed at constructing and reconstructing the Astellolide R scaffold, and each of the pathways offer unique approaches and results, such as using Zirconocene paired with photocatalysis, and getting commercially available products like Drimendiol.
Astellolide R, Sesquiterpenoid, Zirconocene, Drimendiol, Photocatalysis
Baoyi Chen, Ling Hao. Total Synthesis and Retrosynthesis Study of Astellolide R. Academic Journal of Materials & Chemistry (2025), Vol. 6, Issue 3: 98-107. https://doi.org/10.25236/AJMC.2025.060314.
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