This study aimed to evaluate the effect of the fraction of inspired oxygen (FiO₂) before extubation on the washout time of sevoflurane, recovery quality, and the incidence of early postoperative hypoxemia in patients undergoing laparoscopic cholecystectomy, in order to assess the effectiveness of preoxygenation prior to extubation. Sixty patients classified as American Society of Anesthesiologists physical status I–II, aged 18–60 years and with a body mass index of 18–30 kg/m², scheduled for laparoscopic cholecystectomy, were randomly assigned to two groups according to the inhaled oxygen concentration: 50% (Group A, n = 30) and 100% (Group B, n = 30). The time for end-tidal sevoflurane concentration to decrease from 0.8 to 0.2 minimum alveolar concentration (MAC), time to eye opening, time to extubation, Steward scores immediately after extubation (T1), at 3 minutes (T2), and at 5 minutes (T3) after extubation, the incidence of postoperative hypoxemia, and patient satisfaction assessed using the Likert scale were recorded. Compared with Group B, patients in Group A exhibited a significantly shorter sevoflurane washout time (P < 0.05) and higher Steward scores at T₁ and T₂ (P < 0.05). No significant differences were observed between the two groups in terms of time to eye opening, time to extubation, Steward score at T₃, incidence of postoperative hypoxemia, or patient satisfaction. These results suggest that a lower FiO₂ (50%) prior to extubation shortens sevoflurane washout time and improves early recovery quality without increasing the risk of postoperative hypoxemia.

Song Junli, Zeng Jingzheng, Shi Qin, Gong Gu. Effect of Inhaled Oxygen Concentration before Extubation on the Recovery Period of Patients Undergoing Laparoscopic Cholecystectomy. Academic Journal of Medicine & Health Sciences (2025), Vol. 6, Issue 9: 1-7. https://doi.org/10.25236/AJMHS.2025.060901.

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