Frontiers in Medical Science Research, 2026, 8(2); doi: 10.25236/FMSR.2026.080203.
Mengdan Deng1, Wenting Zhang1
1Department of Cardiovascular Medicine, Tangdu Hospital, Fourth Military Medical University, Xi’an, China
This study aimed to systematically evaluate the status and influencing factors of frailty in elderly stroke patients in China. Methods Literature about the incidence and influencing factors of frailty in elderly stroke patients in China were retrieved from CNKI, Wanfang database, VIP, CBM, PubMed, Embase, Web of Science and Cochrane Library. The retrieval time was from the establishment of the database to June 2024. Meta-analysis was performed using RevMan5.3 and Stata 14.0 software. Results A total of 20 articles were included. The results of Meta-analysis showed that the incidence of frailty in elderly stroke patients in China was 49.0 % [95 % CI (38.0 % -60.0 % ) ]. Among them, age, malnutrition, multi-disease coexistence, depression, sleep disorders, impaired activities of daily living, severe neurological impairment, multiple medication, history of falls, and living alone were risk factors; physical exercise is a protective factor. Conclusion The incidence of frailty in elderly stroke patients in China is high, and there are many risk factors. Medical staff should pay attention to the early screening and identification of risk factors in elderly stroke patients to reduce the occurrence of frailty.
stroke; frailty; old age; incidence rate; influencing factors; meta-analysis
Mengdan Deng, Wenting Zhang. Meta-analysis of the incidence and influencing factors of frailty in elderly stroke patients in China. Frontiers in Medical Science Research (2026), Vol. 8, Issue 2: 21-29. https://doi.org/10.25236/FMSR.2026.080203.
[1] Cui Liying, Beijing Physician Association. Neurology [M]. Beijing : China Pharmaceutical Science and Technology Press, 2014.
[2] TSAO C W, ADAY A W, ALMARZOOQ Z I, et al. Heart disease and stroke statistics—2022 update: a report from the American Heart Association [J]. Circulation, 2022, 145 (8) :e153-e639.
[3] Jiang Zhiyue, Li Yumei, Wang Xiuhong, et al. A case-control study on the relationship between common chronic diseases and disability in the elderly at home [J]. Chinese General Practice, 2019, 22 (13) : 1587-1591.
[4] Fried LP, Ferrucci L, Darer J, et al. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care[J]. J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63.
[5] Yanase T, Yanagita I, Muta K, et al. Frailty in elderly diabetes patients [J].Endocrine journal,2018,65(1): 1-11.
[6] PINHO J, KUPPERS C, NIKOUBASHMAN O, et al. Frailty is an outcome predictor in patients with acute ischemic stroke receiving endovascular treatment [J]. Age Ageing, 2021, 50(5) :1785-1791.
[7] Wells G, Shea B, O'Connell D, et al. NewCastle-Ottawa Quality Assessment Scale-Case Control Studies[EB/OL]. [2012-06-15].https://doi.org/10.3390/publications14010004
[8] Li Binghui, Zi Hao, Li Luyao, etc. Methodological quality ( risk of bias ) evaluation tool for primary and secondary studies in the medical field [J]. Medical New Knowledge, 2021,31 (01) : 51-58.
[9] Fan Fanfan, Yang Cui, Wang Qingsong. Correlation between frailty and post-stroke cognitive impairment in elderly patients with ischemic stroke[J].Chinese Journal of Geriatric Cardio-cerebrovascular Disease, 2018,20 (12) : 1253-1257.
[10] Shang Xiaofeng, Zhang Ying, Li Hong, et al. Study on the correlation between frailty and post-stroke depression in elderly patients with acute ischemic stroke [J].General Practice of China, 2020,23 (30) : 3834-3838.
[11] Zhao Jiaqi. Study on the correlation between frailty and depression in elderly stroke patients [ D ]. Liaoning University of Traditional Chinese Medicine, 2020.
[12] Lin Wei, Su Lili, Yu Tianzhi, et al. Investigation of frailty in elderly patients with ischemic stroke sequelae and analysis of its risk factors [J].Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease, 2021,23 (05) : 499-502.
[13] Xia Hanyue, Cao Qian, Zhou Dandan.Analysis of frailty status and influencing factors in elderly stroke patients[J].Shanghai Nursing, 2022,22 (1) : 28-32.
[14] Liu Lingling. Study on the current situation and influencing factors of frailty in elderly stroke patients [D].Hunan University of Traditional Chinese Medicine, 2022.
[15] Wang Lingyu, Hu Xiaolong, Wang Xuejing, et al. The predictive value of frailty index based on comprehensive geriatric assessment for frailty in patients with ischemic stroke [J]. Chinese Journal of Modern Nursing, 2022,28 (2) : 167-171.
[16] Dou Li, Sun Jingjing, Ma Yuting.Analysis of frailty status and its influencing factors in elderly stroke patients [J].Reflection therapy and rehabilitation medicine, 2023,4 (16) : 120-123.
[17] Zhang Xinyu, Zhang Lei, Sui Rubo. Construction of frailty prediction model for elderly stroke patients based on Logistic regression and artificial neural network [J].Military nursing, 2023,40 (02) : 10-14 + 19.
[18] Gao Xiao. Analysis of influencing factors of frailty in elderly patients with ischemic stroke and construction of risk nomogram prediction model [J].Shandong University of Traditional Chinese Medicine, 2023.
[19] Huang Jiao Jiao, Li Xingchen, Zhou Jinjin. Evaluation of frailty in elderly hospitalized stroke patients and its influencing factors [J]. China Health Engineering, 2023, 22 (04) : 484-486.
[20] Qiao Huijuan, Zhang Xiangzhi. Analysis of frailty and its related risk factors in elderly patients with cerebral infarction sequelae[J].Aerospace Medicine Journal, 2023,34 (07) : 791-794.
[21] Huang Yanan. Study on the status of frailty in elderly stroke patients and its correlation with post-stroke cognitive impairment [D].Lanzhou University, 2023.
[22] Zhao Yidi, Liao Ruotong, Zhang Xiaopei, et al. Frailty in elderly stroke patients aged 60 years and older : A cross-sectional survey from a Chinese community[J]. Integrative Chinese and Western Medicine Nursing, 2023, 9 (07) : 134-140.
[23] Qian Junhong, Liu Zhiwei, Li Yan, et al. Longitudinal study of frailty trajectory and influencing factors in rural elderly stroke patients [J].Chinese Journal of Practical Neurological Disorders, 2023,26 (06) :748-754.
[24] Chen Zhangjing, Kong Xianbo, the king 's concubines, etc. Establishment and validation of a predictive model for frailty syndrome in elderly patients with acute ischemic stroke after treatment [J].Chinese Journal of Geriatric Cardio-cerebrovascular Disease, 2023,25 ( 12 ) : 1336-1339.
[25] Wang Ruijuan, Wang Yan. The influencing factors of frailty in elderly patients with ischemic stroke and its relationship with nutritional status and cognitive function [J].Geriatric medicine and health care, 2024,30 ( 02 ) : 353-357.
[26] Jiang Xiaoling, Li Min, Wang Ling. Analysis of influencing factors of frailty in elderly patients with ischemic stroke and construction of risk prediction model [J].Journal of Bengbu Medical College, 2024,49 ( 06 ) : 784-789.
[27] Zhang Linghui, Wang Yaxi, Chen Chen, etc. Prospective study on predictive model of frailty after ischemic stroke in elderly patients [J].General nursing, 2024,22 (08) : 1398-1404.
[28] Wang Genqun, Zhang Lifeng, Luo Yi, Zhan Baixue, Long Yingni. Study on the current situation and influencing factors of frailty in elderly stroke patients in the community [J].Chongqing Medical, 2024,53 (1) : 28-3237.
[29] Burton JK, Stewart J, Blair M,et al. Prevalence and implications of frailty in acute stroke: systematic review & meta-analysis[J]. Age Ageing. 2022 Mar 1;51(3):afac064.
[30] Verschoor CP, Tamim H. Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging [J]. J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):675-682.
[31] Diehl M, Wettstein M, Spuling SM,et al.Age-related change in self-perceptions of aging: Longitudinal trajectories and predictors of change[J]. Psychol Aging. 2021 May;36(3):344-359.
[32] Alonso-Bouzón C, Carcaillon L, García-García FJ, et al. Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging[J]. Age (Dordr). 2014 Feb;36(1):495-505.
[33] Song Yingying, Lin Ziwei, Ding Miaomiao, et al. Analysis of the correlation and influencing factors of frailty in hospitalized elderly patients with atrial fibrillation [J].Journal of Bengbu Medical College, 2021,46 (10) : 1365.
[34] Tornero-Quiñones I, Sáez-Padilla J, Espina Díaz A, et al. Functional Ability, Frailty and Risk of Falls in the Elderly: Relations with Autonomy in Daily Living[J]. Int J Environ Res Public Health. 2020 Feb 5;17(3):1006.
[35] Xu Lijuan, Zhang Lihong, Ye Lina, et al. Community frailty risk factors and risk prediction model construction [J]. Chinese Journal of Geriatrics, 2021,41 (1) : 170-173.
[36] Wai JL, Yu DS. The relationship between sleep-wake disturbances and frailty among older adults: A systematic review[J]. J Adv Nurs. 2020 Jan;76(1):96-108.
[37] LI Xiaoxing, Bolin, ZHU Hongwei, et al. Study on the correlation between sleep disorders and frailty in elderly inpatients [J]. Practical Geriatrics, 2021,35 (1) : 24-27.
[38] Gallacher K.I., Jani B.D., Hanlon P., et al. Multimorbidity in Stroke[J]. Stroke,2019,50(7):1919-1926.
[39] Qi, Zhang, Wang et al. Correlation between swallowing experience and frailty and nutritional status in elderly stroke inpatients [J].China Rehabilitation Theory and Practice, 2020,26 (11) : 1269-1274
[40] Pang Yuanyue, Cao Tongtong, Dong Xue. Research progress on frailty in elderly stroke patients [J].Geriatrics research, 2024,5 (1) : 56-61.
[41] Vaughan L, Corbin AL, Goveas JS. Depression and frailty in later life: a systematic review[J]. Clin Interv Aging. 2015 Dec 15;10:1947-58.
[42] Sun Hui, Xu Jian. Intervention effect of early comprehensive rehabilitation nursing on limb movement and neurological function in stroke patients with hemiplegia [J].Guizhou Medicine, 2021,45 (02) : 330-331.