Hyperbaric oxygen therapy (HBOT) shows promise in stroke rehabilitation. This review explores the impact of combining HBOT with other treatments on functional recovery. A comprehensive search was conducted in CNKI, Wanfang, PubMed and Web of Scienceup to January 1, 2026. After screening, 1867 patients from 18 studies were included. Common HBOT combinations were with exercise therapy (42.1%), magnetic stimulation (15.7%), and intelligent rehabilitation training (10.5%). The mean age was 55.02 years in the HBOT group (male-to-female ratio:1.43) and 55.86 years in the control group (ratio:1.24). The most used assessment scales were the Fugl-Meyer Assessment (78.9%), the Modified Barthel Index (63.2%), and the NIHSS Stroke Scale (36.8%). Compared to the control group, combined HBOT showed significant benefits in neurological and motor function, cognitive ability, and daily living activities. Future research should integrate hyperbaric oxygen therapy with other treatment modalities to more comprehensively evaluate its efficacy. Attention should also be paid to the safety and feasibility of the therapy, assessing the impact of different treatment protocols on patient health, particularly in terms of side effects and long-term dependency. Furthermore, more multicenter, large-sample clinical trials should be conducted, and the integration with intelligent rehabilitation technology should be explored to further enhance therapeutic outcomes.

Donglin Tang, Pavapriya Ponvel. Effects of Hyperbaric Oxygen Combined Rehabilitation Therapy on Patients with Stroke: A-Ten-Year Systematic Review. International Journal of Frontiers in Medicine (2026), Vol. 8, Issue 2: 64-75. https://doi.org/10.25236/IJFM.2026.080208.

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