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The Frontiers of Society, Science and Technology, 2026, 8(4); doi: 10.25236/FSST.2026.080406.

Occurrence and Preliminary Health Risk Assessment of Phenol Residues in Children’s Cosmetics

Author(s)

Dengming Ke, Juyuan Huo, Wenxin Li, Anhong Feng

Corresponding Author:
​Dengming Ke
Affiliation(s)

Shenzhen Academy of Metrology & Quality Inspection, Shenzhen, China, 518100

Abstract

This study systematically investigated the residue levels and distribution characteristics of phenol in commercially available children's cosmetics. A total of 118 batches of children's cosmetics were randomly collected from e-commerce platforms in China. Phenol residues were analyzed using high-performance liquid chromatography with fluorescence detection. The overall detection rate was 24.6%, with residues mainly distributed in the range of 0.20~2.0 mg/kg. A child-specific health risk assessment using the margin of safety (MoS) approach was performed with exposure parameters adjusted for children (daily application amounts derived from SCCS guidelines by body surface area adjustment; dermal absorption rate: 97.6% worst-case; body weights: 9.65 kg for infants 0~3 years for skincare products, 32 kg for school-age children 6~12 years for makeup products). All MoS values for positive samples substantially exceeded the SCCS safety threshold of 100, indicating no significant health risk to children under normal use conditions. However, the detection rate of 24.6% highlights the need for continued monitoring. This study provides baseline occurrence data for phenol residues in children's cosmetics in the Chinese market.

Keywords

Children's cosmetics, Phenol,Residue level,Health risk assessment, Exposure assessment

Cite This Paper

Dengming Ke, Juyuan Huo, Wenxin Li, Anhong Feng. Occurrence and Preliminary Health Risk Assessment of Phenol Residues in Children’s Cosmetics. The Frontiers of Society, Science and Technology (2026), Vol. 8, Issue 4: 33-38. https://doi.org/10.25236/FSST.2026.080406.

References

[1] Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for Phenol. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service; 2008. Available from: https://www.atsdr.cdc.gov/ToxProfiles/tp115-c3.pdf

[2] European Parliament and Council of the European Union. Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (Text with EEA relevance). 2008.

[3] van de Sandt JJM, Rutten AAJJL. Comparative in vitro percutaneous absorption of p-substituted phenols through rat skin using static and flow-through diffusion systems. Toxicology in Vitro. 1993;7(3):221-227.

[4] Scott RC, Batten PL, Clowes HM, Jones BK, Ramsey JD. Percutaneous absorption of nicotinic acid, phenol, benzoic acid and triclopyr butoxyethyl ester through rat and human skin in vitro: further validation of an in vitro model by comparison with in vivo data. Food and Chemical Toxicology. 1992;30(10):891-899.

[5] European Parliament and Council of the European Union. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (Text with EEA relevance). 2009.

[6] National Medical Products Administration (NMPA). Safety and Technical Standards for Cosmetics (2015 Edition). China; 2015.

[7] Scientific Committee on Consumer Safety (SCCS). SCCS notes of guidance for the testing of cosmetic ingredients and their safety evaluation (12th revision). European Commission; 2023. Available from: https://health.ec.europa.eu/publications/sccs-notes-guidance-testing-cosmetic-ingredients-and-their-safety-evaluation-12th-revision_en

[8] Ministry of Ecology and Environment of the People's Republic of China. Exposure Factors Handbook of Chinese Population (Children's Volume: 0–5 Years). Beijing: China Environmental Science Press; 2016.

[9] Ministry of Ecology and Environment of the People's Republic of China. Exposure Factors Handbook of Chinese Population (Children's Volume: 6–17 Years). Beijing: China Environmental Science Press; 2016.

[10] Ministry of Ecology and Environment of the People's Republic of China. Exposure Factors Handbook of Chinese Population (Adult Volume). Beijing: China Environmental Science Press; 2013.

[11] EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). Scientific Opinion on the toxicological evaluation of phenol. EFSA Journal. 2013;11(4):3189.

[12] U.S. Environmental Protection Agency (EPA). Integrated Risk Information System (IRIS) for Phenol. Available from: https://iris.epa.gov/AtoZ/?list_type=alpha