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Frontiers in Medical Science Research, 2019, 1(1); doi: 10.25236/FMSR.20190104.

Advances in the relationship between protein acetylation and sperm DNA stability and sperm motility


Juan Zhang, Hui Li

Corresponding Author:
Juan Zhang

Reproductive Medicine Center of Zhuzhou Central Hospital, Zhuzhou, China


Epigenetics is involved in regulating spermatogenesis and spermatogenesis. Acetylation of histone and non-histone plays a key role in the reconstruction of chromatin structure and sperm motility in spermatogenic cells. The binding protein (CBP) and P300 of cyclic adenosine monophosphate (cAMP) reaction element connexin (CREB) are two acetylase enzymes, which can acetylate core histone, and their acetylation can be inhibited by the acetylase inhibitor (INHAT). Testicle-specific Bromo domain (BRDT) proteins are conserved nucleoproteins that recognize acetylated and non-acetylated histones. In the early stage of spermatogenesis, BRDT regulates gene transcription; in the spermatogenesis stage, BRDT recognizes highly acetylated histones, which are then replaced by protamine to form dense chromatin. Deacetylation of non-histone alpha tubulin (alpha-Tubulin) decreases sperm motility, and acetylated alpha-tubulin (Ac-alpha-Tu) decreases significantly in oligoasthenospermia patients.


Spermatogenesis; Histones; Heredity; Acetylation; Tubulin; Infertility, Male (male) sex

Cite This Paper

Juan Zhang, Hui Li, Advances in the relationship between protein acetylation and sperm DNA stability and sperm motility. Frontiers in Medical Science Research (2019) Vol. 1 Issue 1: 42-47. https://doi.org/10.25236/FMSR.20190104.


[1]Wu JL, Kang XJ, Guo MS, et al(2015). Cloning and Functional Analysis of Histones H3 and H4 in Nuclear Shaping during Spermatogenesis of the Chinese Mitten Crab, Eriocheir sinensis . PLoS One, vol.10, no. 5, pp. e0126623.
[2]Kim JH, Jee BC, Lee JM, et al(2014). Histone acetylation level and histone acetyltransferase/deacetylase activity in ejaculated sperm from normozoospermic men. Yonsei Med J, vol.55, no.5, pp.1333-1340.
[3]Kimura S,Loppin B(2015). Two bromodomain proteins functionally interact to recapitulate an essential BRDT -like function in Drosophila spermatocytes. Open Biol,vol.5, no.2, pp.140-145.
[4]Kofman AE,Huszar JM,Payne CJ(2013). Transcriptional analysis of histone deacetylase family members reveal similarities between differentiating and aging spermatogonial stem cells. Stem Cell Rev, vol.9, no.1, pp. 59-64.
[5]Yassin S, Escoffier J, Martinez G, et al. (2015). Dpy19l2 -deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development. Mol Hum Reprod, vol.21, no.2, pp.169-185.
[6]Bhagwat S, Dalvi V, Chandrasekhar D, et al. (2014). Acetylated α-tubulin is reduced in individuals with poor sperm motility. Fertil Steril, vol.101, no.1, pp.95-104.
[7]Kurihara M, Shiraishi A, Satake H, et al. (2014). A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA. J Mol Biol,426, no.17, pp.3069-3093.
[8]Pentakota SK, Sandhya S, P Sikarwar A, et al. (2014). Mapping post -translational modifications of mammalian testicular specific histone variant TH2B in tetraploid and haploid germ cells and their implications on the dynamics of nucleosome structure . J Proteome Res, vol. 13, no.12, pp.5603-5617.
[9]Boussouar F, Goudarzi A, Buchou T, et al. (2014). A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis. Andrology, vol.2, no.3, pp.351-359.
[10]Giotopoulos G,Chan WI,Horton SJ,et al. (2016). The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene, vol.35, no.3, pp.279-289.