In recent years, coronary heart disease and depression are gradually becoming two diseases that endanger human health and impose a huge burden on medical care in various countries. At present, depression has become one of the risk factors of coronary heart disease, and coronary heart disease can increase the incidence of depression, both of which can be seen in the same patient. With the society entering a new era, the traditional medical model has gradually changed to the bio-psycho-social medical model, and it is particularly important to explore the co-disease mechanism of coronary heart disease and depression based on the framework of bicardiac medicine. it has important clinical significance for disease prevention, early intervention and late treatment.

Xiaolong Gao, Junru Zhang. Study on the Comorbid Mechanism and Treatment of Coronary Heart Disease and Depression under the Framework of Bicardiac Medicine. Frontiers in Medical Science Research (2022) Vol. 4, Issue 4: 55-63. https://doi.org/10.25236/FMSR.2022.040409.

[1] M De Hert, Detraux J, Vancampfort D. The intriguing relationship between coronary heart disease and mental disorders [J]. Dialogues Clin Neurosci, 2018, 20(1): 31-40.

[2] R-M Carney, Freedland K-E, Steinmeyer B-C, et al. Residual Symptoms After Treatment for Depression in Patients with Coronary Heart Disease [J]. Psychosom Med, 2018, 80(4): 385-392.

[3] C-B Nemeroff, Goldschmidt-Clermont P-J. Heartache and heartbreak--the link between depression and cardiovascular disease [J]. Nat Rev Cardiol, 2012, 9(9): 526-539.

[4] B-D Thombs, Bass E-B, Ford D-E, et al. Prevalence of depression in survivors of acute myocardial infarction [J]. J Gen Intern Med, 2006, 21(1): 30-38.

[5] A Wynn. Unwarranted emotional distress in men with ischaemic heart disease (IHD)[J]. Med J Aust, 1967, 2(19): 847-851.

[6] E-L Cay, Vetter N, Philip A-E, et al. Psychological status during recovery from an acute heart attack [J]. J Psychosom Res, 1972, 16(6): 425-435.

[7] T Suzuki, Shiga T, Kuwahara K, et al. Prevalence and persistence of depression in patients with implantable cardioverter defibrillator: a 2-year longitudinal study [J]. Pacing Clin Electrophysiol, 2010, 33(12): 1455-1461.

[8] D-M Colquhoun, Bunker S-J, Clarke D-M, et al. Screening, referral and treatment for depression in patients with coronary heart disease [J]. Med J Aust, 2013, 198(9): 483-484.

[9] D Whitehead, Bodenlos J-S, Cowles M-L, et al. A stage-targeted physical activity intervention among a predominantly African-American low-income primary care population [J]. Am J Health Promot, 2007, 21(3): 160-163.

[10] K-L Huang, Su T-P, Chen T-J, et al. Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study [J]. Psychiatry Clin Neurosci, 2009, 63(3): 401-409.

[11] C-J Holahan, Pahl S-A, Cronkite R-C, et al. Depression and vulnerability to incident physical illness across 10 years [J]. J Affect Disord, 2010, 123(1-3): 222-229.

[12] A-J Shah, Veledar E, Hong Y, et al. Depression and history of attempted suicide as risk factors for heart disease mortality in young individuals [J]. Arch Gen Psychiatry, 2011, 68(11): 1135-1142.

[13] R Peters, Pinto E, Beckett N, et al. Association of depression with subsequent mortality, cardiovascular morbidity and incident dementia in people aged 80 and over and suffering from hypertension. Data from the Hypertension in the Very Elderly Trial (HYVET) [J]. Age Ageing, 2010, 39(4): 439-445.

[14] CAO Juan, LIU Xijian, GONG Ting, et al. Progress on the mechanism and treatment of patients with coronary artery disease and comorbid depression[J]. Chemistry of life, 2019, 39(05):993-997.

[15] P de Jonge, Rosmalen J-G, Kema I-P, et al. Psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients: a critical review of the literature [J]. Neurosci Biobehav Rev, 2010, 35(1): 84-90.

[16] M-B Howren, Lamkin D-M, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis [J]. Psychosom Med, 2009, 71(2): 171-186.

[17] M Maes, Carvalho A-F. The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder [J]. Mol Neurobiol, 2018, 55(12): 8885-8903.

[18] H Pikhart, Hubacek J-A, Kubinova R, et al. Depressive symptoms and levels of C-reactive protein: a population-based study[J]. Soc Psychiatry Psychiatr Epidemiol, 2009, 44(3): 217-222.

[19] M Elovainio, Aalto A-M, Kivimaki M, et al. Depression and C-reactive protein: population-based Health 2000 Study [J]. Psychosom Med, 2009, 71(4): 423-430.

[20] J Collins, Tessaro M-O, McGovern T. Esophageal bougienage in the emergency department with a substitute Hurst dilator [J]. Am J Emerg Med, 2020, 38(1): 163.

[21] I Janszky, Ahlbom A, Hallqvist J, et al. Hospitalization for depression is associated with an increased risk for myocardial infarction not explained by lifestyle, lipids, coagulation, and inflammation: the SHEEP Study [J]. Biol Psychiatry, 2007, 62(1): 25-32.

[22] P-G Surtees, Wainwright N-W, Luben R-N, et al. Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort study [J]. Am J Psychiatry, 2008, 165(4): 515-523.

[23] C-B Nemeroff, Goldschmidt-Clermont P-J. Heartache and heartbreak--the link between depression and cardiovascular disease [J]. Nat Rev Cardiol, 2012, 9(9): 526-539.

[24] M-C Morel-Kopp, McLean L, Chen Q, et al. The association of depression with platelet activation: evidence for a treatment effect [J]. J Thromb Haemost, 2009, 7(4): 573-581.

[25] PENG Min, PU Wei-dan, YU Shun-ying et al. BDNF Gene Polymorphism, Platelet Activityand Depressive Mood in CAD Patients [J]. Chinese Journal of Clinical Psychology, 2018, 26(02): 230-233.

[26] LI Dan, LI Yu-jie, YANG Qing, et al. Research Progress of Endothelial Dysfunction and Atherosclerosis [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2012, 18(08): 272-276.

[27] M-M Burg, Martens E-J, Collins D, et al. Depression predicts elevated endothelin-1 in patients with coronary artery disease [J]. Psychosom Med, 2011, 73(1): 2-6.

[28] D-C Cooper, Tomfohr L-M, Milic M-S, et al. Depressed mood and flow-mediated dilation: a systematic review and meta-analysis [J]. Psychosom Med, 2011, 73(5): 360-369.

[29] J-L Greaney, Saunders EFH, Santhanam L, et al. Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women with Major Depressive Disorder [J]. Circ Res, 2019, 124(4): 564-574.

[30] C-B Nemeroff, Goldschmidt-Clermont P-J. Heartache and heartbreak--the link between depression and cardiovascular disease [J]. Nat Rev Cardiol, 2012, 9(9): 526-539.

[31] Ying An1, Ji-qiu Hou1, Ya-li Chen et al. Effects of antidepressants on efficacy and inflammatory factors in patients with coronary heart disease with depression: a meta-analysis [J]. China Journal of Modern Medicine,2021, 31(03): 84-91.

[32] B Phillips-Bute, Mathew J-P, Blumenthal J-A, et al. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery [J]. Psychosom Med, 2008, 70(9): 953-959.

[33] H Welper, Aller A, Guttenthaler V, et al. [Serotonin transporter gene and stress reactivity in unipolar depression. Role of the HPA system as endophenotype of the SLC6A4 gene [J]. Nervenarzt, 2014, 85(3): 336-338, 340-343.

[34] G-E Miller, Stetler C-A, Carney R-M, et al. Clinical depression and inflammatory risk markers for coronary heart disease [J]. Am J Cardiol, 2002, 90(12): 1279-1283.

[35] J Brandt, Warnke K, Jorgens S, et al. Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study [J]. J Neural Transm (Vienna), 2020, 127(12): 1651-1662.

[36] C-N Black, Bot M, Scheffer P-G, et al. Is depression associated with increased oxidative stress? A systematic review and meta-analysis [J]. Psychoneuroendocrinology, 2015, 51164-175.

[37] N Rodondi, den Elzen W-P, Bauer D-C, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality [J]. JAMA, 2010, 304(12): 1365-1374.

[38] Li Ye. Research Progress on the relationship between depression and cardiovascular disease [J]. Journal of Harbin Medical University, 2013, 47(02): 194-196.

[39] R Hartmann, Schmidt F-M, Sander C, et al. Heart Rate Variability as Indicator of Clinical State in Depression [J]. Front Psychiatry, 2018, 9735.

[40] Zhang Lijun, Huang Shutian, sun Lili, et al. Effect of psychological intervention on patients with coronary heart disease with anxiety and depression [J]. Chinese Journal of cardiovascular research, 2014, 12(11): 965-968.

[41] Zhou Ying, Chen Zhiliang, Gu Ning. Professor Gu Ning's Thoughts on syndrome differentiation and treatment of "double heart disease" and examples of clinical cases [J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2020, 29(36): 4076-4079.

[42] Yuan Zhuo, Zhang Junping. Depression and collateral damage in coronary heart disease [J]. Journal of Shanghai University of Traditional Chinese Medicine, 2007, (01): 31-32.

[43] Li Cheng, Hua Xin, Zhu aisong, et al. To explore the pathogenesis of coronary heart disease with anxiety and depression from the combination of blood stasis, toxin and depression [J]. Journal of Traditional Chinese Medicine, 2021, 62(03): 195-198.

[44] Gao Denan.Clinical observation of modified Xuefu Zhuyu Decoction in the treatment of coronary heart disease complicated with mild depression [J]. Cardiovascular Disease Electronic Journal of integrated traditional Chinese and Western Medicine, 2019, 7(26): 146-158.

[45] ZHU Wenxiu, TANG Xianwen.YANG Jinguo et al. Clinical effect of Shugan Yangxin decoction in treatment of patients with coronary heart disease and depression: An analysis of 30 cases [J]. Hunan Journal of Traditional Chinese Medicine, 2019, 35(12): 1-3.

[46] Xuan Zhihong, Lou Yiping. Effect of Shugan Jieyu Decoction on coronary heart disease with depression[J]. Chinese Journal of Rural Medicine and Pharmacy, 2019, 26(08): 37-38.