Cancer of Colon (CRC) is one of the most common gastrointestinal malignancies in the world and the third most common cancer in the world [1]. Clinically, markers such as carcinoembryonic antigen (CEA) are widely used in early treatment, but their sensitivity is poor, especially in diagnosis and treatment. In order to improve the efficiency of diagnosis and treatment of early CRC, it is necessary to find new sensitive biomarkers. In recent years, more and more attention has been paid to the role of exosomes in human malignant tumors. Studies have shown that plasma exosome microRNAs (miRs) mediate the occurrence, development, invasion, metastasis and other biological behaviors of tumors [2-3]. At present, radical surgical treatment is often used in clinical treatment. There are certain limitations in combining chemotherapy and other means after surgery, and the toxic and side effects of patients are more prominent, bringing severe pain to patients. TCM treatment has certain advantages, so finding drugs that can efficiently kill tumor cells and have little toxic and side effects is a hot spot in the research and development of anti-tumor new drugs today [4].

Haonan Chen, Xuehui Zhou, Akida·Akbar, Xu Deng. The relationship between miRNA and colon cancer. Frontiers in Medical Science Research (2022) Vol. 4, Issue 8: 11-14. https://doi.org/10.25236/FMSR.2022.040803.

[1] Zhu Yingchao, Hu Fei, Bu Shizhong. Research progress of obesity and colon cancer [J]. Chem biol, 2020, 40(04): 585-592.

[2] Xue Yuan, Li Peidong, Zhang Guangjun. Research progress of microRNAs of serum exosomes in patients with colorectal cancer [J]. Chin J general gynecol clin, 2020, 27(09): 1169-1174.

[3] Ingenito F, Roscigno G, Affinito A, et al. The role of exo-miRNAs in cancer: a focus on therapeutic and diagnostic applications. Int J Mol Sci, 2019, 20(19): E4687.

[4] Zhang Tao, Kang Xiangdong. Research progress of traditional Chinese and western medicine in the treatment of colon cancer [J]. Systemic medicine,2019,4(23):192-194.

[5] Li Xiao, Liu Lingying, Chai Jiake. Journal of PLA medical college, 2015, 36(10): 1042-1044+1051. (In Chinese)

[6] Fu Yawen, Gao Feng, DuYuzhen. The role of exosomes in the formation of microenvironment before tumor metastasis [J]. Modern oncology, 2020, 28(23): 4167-4170.

[7] Liu Hang, Li Xian, Zhang Lin, Wang Guanghui, Ding Jie. Progress and significance of exosomal miRNA in diagnosis of colorectal cancer [J]. Medical review, 2020, 26(21): 4219-4224.

[8] Suzuki H, Yamagata K, Sugimoto K, et al. Modulation of microRNA processing by Modulation of p53 [J]. Nature, 2009, 460 (7254): 529-533.

[9] Baraniskin A, Maike A, Steffen GJ, et al. Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal Adenocarcinoma [J]. Int J Cancer, 2013, 132 (2): e48-E57.

[10] Sun W. The role of Mir-150 in the proliferation and metastasis of hepatocellular carcinoma and its related mechanisms [D]. Fourth Military Medical University, 2016.

[11] Chen X, Xu X, Pan B, et al. miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer [J]. Aging (Albany NY), 2018, 10(11): 3421-3437.

[12] Wu Q, Jin H, Yang Z, et al. Negatively-regulating function of mir-150 and negatively regulating the pro-apoptotic gene EGR2 [J]. Biochem Biophys Res Commun, 2010, 392 (3): 340-345.

[13] Liu Jie, Zhang Wentian, DU Jinbo. Expression of Mir-21 and C-Met in colon cancer and its clinical significance [J]. China medical review, 2020, 17(17): 121-124.

[14] Ma Q, Ma Q, Ma J, et al. The effect of astrocyte exosome Mir-21 on the migration of pancreatic cancer cells and SERP1, a prognostic marker of pancreatic cancer [J]. Peking Union Medical College,2018.

[15] Au Yeung CL, Co NN, Tsuruga T, etal: Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF 1. Nat Commun 7: 11150, 2016

[16] Guo Shuchuang. Expression of serum exosome Mir-92a in colorectal cancer and its prognostic significance [D]. Southern Medical University, 2020.