Alzheimer's disease (AD) is a degenerative disease of the nervous system. Mainly presenting with neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language disorders [1]. Also known as senile dementia, it is the leading cause of dementia in the elderly [2]. Involved in 60-80% of all reports of dementia [3]. As the global population ages, AD prevalence and mortality rates increase. It seriously affects the quality of life of the elderly and brings a heavy economic burden and severe social problems. The tea polyphenol epigallocatechin gallate (EGCG) has preventive and therapeutic effects on Alzheimer's disease by inhibiting the amyloid formation and aggregation, antioxidant, anti-inflammatory, metal chelating, binding cholinesterase, thereby reducing the degradation of acetylcholine, and repairing mitochondrial dysfunction. This article reviews the research on the mechanism of EGCG action on Alzheimer's disease.

Lin Meng, Changxing Liu, Lili Yuan, Xiang Chang. Research progress of EGCG in the treatment of Alzheimer's disease. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 6: 48-56. https://doi.org/10.25236/IJFM.2022.040609.

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